Abstract
Scleroderma is a multisystem disease characterized by cutaneous and visceral fibrosis. Skin disease is both a disabling feature of scleroderma and a predictor of visceral involvement. The established method of skin assessment is the modified Rodnan skin score (MRSS) which uses semi-quantitative manual skin scoring. However, the Rodnan method is subjective. We have developed a technique and system for assessing skin health by producing and analyzing surface waves in the skin to determine the skin viscoelastic properties. Viscoelasticity of human skin is measured on 30 healthy volunteers and 10 scleroderma patients at six anatomic sites. A small force, monitored by a force transducer, is applied to the skin using a ball-tipped device attached to a mechanical shaker. The skin motion is measured by a scanning laser vibrometer. The surface wave speed is measured by the phase gradient method. The viscoelasticity is inversely estimated by the wave speed dispersion. A typical measurement of the surface wave speed is 3.25±0.19m/s on the forearm of a volunteer at 200Hz. With the wave speed dispersion from 100Hz to 400Hz, the shear elasticity μ1 and shear viscosity μ2 are estimated, respectively, 7.86±1.86kPa and 5.03±0.60Pa on the forearm. Statistical analyses suggest that there are significant differences of viscoelasticity between scleroderma patients and healthy subjects. Scleroderma can be effectively and quantitatively evaluated based on human skin viscoelasticity.
Original language | English (US) |
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Pages (from-to) | 31-37 |
Number of pages | 7 |
Journal | Medical Engineering and Physics |
Volume | 33 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2011 |
Keywords
- Quantitative
- Scleroderma
- Skin
- Surface wave
- Viscoelasticity
ASJC Scopus subject areas
- Biophysics
- Biomedical Engineering