Quantitative assessment of pulmonary perfusion with dynamic contrast- enhanced MRI

Hiroto Hatabu, Eiji Tadamura, David L. Levin, Qun Chen, Wei Li, Ducksoo Kim, Pottumarthi V. Prasad, Robert R. Edelman

Research output: Contribution to journalArticlepeer-review

158 Scopus citations

Abstract

The feasibility of qualitative assessment of pulmonary perfusion using dynamic contrast enhanced MRI with ultra-short TE has recently been demonstrated. In the current study, quantitative analysis was attempted based on the indicator dilution principle using a pig model of pulmonary embolism. The results were compared with the absolute pulmonary perfusion obtained with colored microspheres. The inverse of apparent mean transit time (1/τ(app)), distribution volume (V), and V/τ(app) were correlated well with the absolute lung perfusion. This study demonstrates that MR has the potential to evaluate pulmonary perfusion quantitatively.

Original languageEnglish (US)
Pages (from-to)1033-1038
Number of pages6
JournalMagnetic Resonance in Medicine
Volume42
Issue number6
DOIs
StatePublished - 1999

Keywords

  • Lung, perfusion
  • Magnetic resonance
  • Pulmonary artery

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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