Abstract
Logopenic primary progressive aphasia (lvPPA) typically results from underlying Alzheimer's disease, but subjects have been reported that do not show beta-amyloid (Aβ) deposition. These subjects do not differ on neurological and speech-language testing from Aβ-positive lvPPA, but they impressionistically show increased grammatical deficits. We performed a quantitative linguistic analysis of grammatical characteristics in Aβ-negative lvPPA compared to Aβ-positive lvPPA and agrammatic PPA, which is characterized by increased grammatical difficulties. Aβ-negative lvPPA used fewer function words and correct verbs but more syntactic and semantic errors compared to Aβ-positive lvPPA. These measures did not differ between Aβ-negative lvPPA and agPPA. Both lvPPA cohorts showed a higher mean length of utterance, more complex sentences, and fewer nouns than agPPA. Aβ-negative lvPPA subjects appear unique and share linguistic features with both agPPA and Aβ-positive lvPPA. Quantitative language analysis in lvPPA may be able to distinguish those with and without Aβ deposition.
Original language | English (US) |
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Pages (from-to) | 26-31 |
Number of pages | 6 |
Journal | Brain and Language |
Volume | 186 |
DOIs | |
State | Published - Nov 2018 |
Keywords
- Agrammatism
- Amyloid
- Aphasia
- Logopenic
- Logopenic aphasia
- PET
- Primary progressive aphasia
- Syntax
ASJC Scopus subject areas
- Language and Linguistics
- Experimental and Cognitive Psychology
- Linguistics and Language
- Cognitive Neuroscience
- Speech and Hearing