Quantitative assessment of grammar in amyloid-negative logopenic aphasia

Katerina A. Tetzloff, Jennifer Lynn Whitwell, Rene Utianski, Joseph R. Duffy, Heather Clark, Mary Margaret Machulda, Edythe A. Strand, Keith Anthony Josephs

Research output: Contribution to journalArticle

Abstract

Logopenic primary progressive aphasia (lvPPA) typically results from underlying Alzheimer's disease, but subjects have been reported that do not show beta-amyloid (Aβ) deposition. These subjects do not differ on neurological and speech-language testing from Aβ-positive lvPPA, but they impressionistically show increased grammatical deficits. We performed a quantitative linguistic analysis of grammatical characteristics in Aβ-negative lvPPA compared to Aβ-positive lvPPA and agrammatic PPA, which is characterized by increased grammatical difficulties. Aβ-negative lvPPA used fewer function words and correct verbs but more syntactic and semantic errors compared to Aβ-positive lvPPA. These measures did not differ between Aβ-negative lvPPA and agPPA. Both lvPPA cohorts showed a higher mean length of utterance, more complex sentences, and fewer nouns than agPPA. Aβ-negative lvPPA subjects appear unique and share linguistic features with both agPPA and Aβ-positive lvPPA. Quantitative language analysis in lvPPA may be able to distinguish those with and without Aβ deposition.

Original languageEnglish (US)
Pages (from-to)26-31
Number of pages6
JournalBrain and Language
Volume186
DOIs
StatePublished - Nov 1 2018

Fingerprint

Aphasia
speech disorder
Linguistics
Amyloid
grammar
Language
Primary Progressive Aphasia
Semantics
language analysis
linguistics
Alzheimer Disease
dementia
deficit
semantics
language
Grammar
Deposition
Language Testing
Cohort
Semantic Errors

Keywords

  • Agrammatism
  • Amyloid
  • Aphasia
  • Logopenic
  • Logopenic aphasia
  • PET
  • Primary progressive aphasia
  • Syntax

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Language and Linguistics
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing

Cite this

Quantitative assessment of grammar in amyloid-negative logopenic aphasia. / Tetzloff, Katerina A.; Whitwell, Jennifer Lynn; Utianski, Rene; Duffy, Joseph R.; Clark, Heather; Machulda, Mary Margaret; Strand, Edythe A.; Josephs, Keith Anthony.

In: Brain and Language, Vol. 186, 01.11.2018, p. 26-31.

Research output: Contribution to journalArticle

@article{e1528040b12c4a008c482bccc7947469,
title = "Quantitative assessment of grammar in amyloid-negative logopenic aphasia",
abstract = "Logopenic primary progressive aphasia (lvPPA) typically results from underlying Alzheimer's disease, but subjects have been reported that do not show beta-amyloid (Aβ) deposition. These subjects do not differ on neurological and speech-language testing from Aβ-positive lvPPA, but they impressionistically show increased grammatical deficits. We performed a quantitative linguistic analysis of grammatical characteristics in Aβ-negative lvPPA compared to Aβ-positive lvPPA and agrammatic PPA, which is characterized by increased grammatical difficulties. Aβ-negative lvPPA used fewer function words and correct verbs but more syntactic and semantic errors compared to Aβ-positive lvPPA. These measures did not differ between Aβ-negative lvPPA and agPPA. Both lvPPA cohorts showed a higher mean length of utterance, more complex sentences, and fewer nouns than agPPA. Aβ-negative lvPPA subjects appear unique and share linguistic features with both agPPA and Aβ-positive lvPPA. Quantitative language analysis in lvPPA may be able to distinguish those with and without Aβ deposition.",
keywords = "Agrammatism, Amyloid, Aphasia, Logopenic, Logopenic aphasia, PET, Primary progressive aphasia, Syntax",
author = "Tetzloff, {Katerina A.} and Whitwell, {Jennifer Lynn} and Rene Utianski and Duffy, {Joseph R.} and Heather Clark and Machulda, {Mary Margaret} and Strand, {Edythe A.} and Josephs, {Keith Anthony}",
year = "2018",
month = "11",
day = "1",
doi = "10.1016/j.bandl.2018.09.003",
language = "English (US)",
volume = "186",
pages = "26--31",
journal = "Brain and Language",
issn = "0093-934X",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Quantitative assessment of grammar in amyloid-negative logopenic aphasia

AU - Tetzloff, Katerina A.

AU - Whitwell, Jennifer Lynn

AU - Utianski, Rene

AU - Duffy, Joseph R.

AU - Clark, Heather

AU - Machulda, Mary Margaret

AU - Strand, Edythe A.

AU - Josephs, Keith Anthony

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Logopenic primary progressive aphasia (lvPPA) typically results from underlying Alzheimer's disease, but subjects have been reported that do not show beta-amyloid (Aβ) deposition. These subjects do not differ on neurological and speech-language testing from Aβ-positive lvPPA, but they impressionistically show increased grammatical deficits. We performed a quantitative linguistic analysis of grammatical characteristics in Aβ-negative lvPPA compared to Aβ-positive lvPPA and agrammatic PPA, which is characterized by increased grammatical difficulties. Aβ-negative lvPPA used fewer function words and correct verbs but more syntactic and semantic errors compared to Aβ-positive lvPPA. These measures did not differ between Aβ-negative lvPPA and agPPA. Both lvPPA cohorts showed a higher mean length of utterance, more complex sentences, and fewer nouns than agPPA. Aβ-negative lvPPA subjects appear unique and share linguistic features with both agPPA and Aβ-positive lvPPA. Quantitative language analysis in lvPPA may be able to distinguish those with and without Aβ deposition.

AB - Logopenic primary progressive aphasia (lvPPA) typically results from underlying Alzheimer's disease, but subjects have been reported that do not show beta-amyloid (Aβ) deposition. These subjects do not differ on neurological and speech-language testing from Aβ-positive lvPPA, but they impressionistically show increased grammatical deficits. We performed a quantitative linguistic analysis of grammatical characteristics in Aβ-negative lvPPA compared to Aβ-positive lvPPA and agrammatic PPA, which is characterized by increased grammatical difficulties. Aβ-negative lvPPA used fewer function words and correct verbs but more syntactic and semantic errors compared to Aβ-positive lvPPA. These measures did not differ between Aβ-negative lvPPA and agPPA. Both lvPPA cohorts showed a higher mean length of utterance, more complex sentences, and fewer nouns than agPPA. Aβ-negative lvPPA subjects appear unique and share linguistic features with both agPPA and Aβ-positive lvPPA. Quantitative language analysis in lvPPA may be able to distinguish those with and without Aβ deposition.

KW - Agrammatism

KW - Amyloid

KW - Aphasia

KW - Logopenic

KW - Logopenic aphasia

KW - PET

KW - Primary progressive aphasia

KW - Syntax

UR - http://www.scopus.com/inward/record.url?scp=85052924206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052924206&partnerID=8YFLogxK

U2 - 10.1016/j.bandl.2018.09.003

DO - 10.1016/j.bandl.2018.09.003

M3 - Article

C2 - 30205287

AN - SCOPUS:85052924206

VL - 186

SP - 26

EP - 31

JO - Brain and Language

JF - Brain and Language

SN - 0093-934X

ER -