Quantitative aspects of autocrine regulation in tumors.

Z. Bajzer, S. Vuk-Pavlović

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Autocrine regulation is defined as a mechanism of self-control in growth and differentiation; this mode of regulation among histologically homologous cells is mediated humorally. Autocrine mechanisms involve: 1. Autonomously controlled production and secretion of autocrine mediators. 2. Distribution of autocrine mediators among cells. 3. Expression by cells of functional receptors for autocrine mediators. 4. Transduction and intracellular integration of signals mediated by autocrine mediators. 5. Growth response. 6. Maintenance of autonomous control of growth and/or differentiation state in the progeny Biochemical and biological evidence for most of these steps in various transformed cells makes it possible to analyze autocrine control as a multifaceted process. This process depends on tumor cellularity and histoarchitecture, on time and on external influences on secretion of autocrine mediators (e.g., estrogens in estrogen-dependent breast cancer). We review the quantitative aspects of experimental evidence for autocrine control in tumors and examine the phenomenological and some mechanistic concepts in creating integrative, quantitative, and experimentally verifiable mathematical models of autocrine regulation.

Original languageEnglish (US)
Pages (from-to)53-73
Number of pages21
JournalCritical Reviews in Oncogenesis
Volume2
Issue number1
StatePublished - 1990
Externally publishedYes

Fingerprint

Neoplasms
Estrogens
Growth
Theoretical Models
Maintenance
Breast Neoplasms

ASJC Scopus subject areas

  • Cancer Research

Cite this

Quantitative aspects of autocrine regulation in tumors. / Bajzer, Z.; Vuk-Pavlović, S.

In: Critical Reviews in Oncogenesis, Vol. 2, No. 1, 1990, p. 53-73.

Research output: Contribution to journalArticle

Bajzer, Z & Vuk-Pavlović, S 1990, 'Quantitative aspects of autocrine regulation in tumors.', Critical Reviews in Oncogenesis, vol. 2, no. 1, pp. 53-73.
Bajzer, Z. ; Vuk-Pavlović, S. / Quantitative aspects of autocrine regulation in tumors. In: Critical Reviews in Oncogenesis. 1990 ; Vol. 2, No. 1. pp. 53-73.
@article{092a3ae5cf734e0c99cb80190fda9ba9,
title = "Quantitative aspects of autocrine regulation in tumors.",
abstract = "Autocrine regulation is defined as a mechanism of self-control in growth and differentiation; this mode of regulation among histologically homologous cells is mediated humorally. Autocrine mechanisms involve: 1. Autonomously controlled production and secretion of autocrine mediators. 2. Distribution of autocrine mediators among cells. 3. Expression by cells of functional receptors for autocrine mediators. 4. Transduction and intracellular integration of signals mediated by autocrine mediators. 5. Growth response. 6. Maintenance of autonomous control of growth and/or differentiation state in the progeny Biochemical and biological evidence for most of these steps in various transformed cells makes it possible to analyze autocrine control as a multifaceted process. This process depends on tumor cellularity and histoarchitecture, on time and on external influences on secretion of autocrine mediators (e.g., estrogens in estrogen-dependent breast cancer). We review the quantitative aspects of experimental evidence for autocrine control in tumors and examine the phenomenological and some mechanistic concepts in creating integrative, quantitative, and experimentally verifiable mathematical models of autocrine regulation.",
author = "Z. Bajzer and S. Vuk-Pavlović",
year = "1990",
language = "English (US)",
volume = "2",
pages = "53--73",
journal = "Critical Reviews in Oncogenesis",
issn = "0893-9675",
publisher = "Begell House Inc.",
number = "1",

}

TY - JOUR

T1 - Quantitative aspects of autocrine regulation in tumors.

AU - Bajzer, Z.

AU - Vuk-Pavlović, S.

PY - 1990

Y1 - 1990

N2 - Autocrine regulation is defined as a mechanism of self-control in growth and differentiation; this mode of regulation among histologically homologous cells is mediated humorally. Autocrine mechanisms involve: 1. Autonomously controlled production and secretion of autocrine mediators. 2. Distribution of autocrine mediators among cells. 3. Expression by cells of functional receptors for autocrine mediators. 4. Transduction and intracellular integration of signals mediated by autocrine mediators. 5. Growth response. 6. Maintenance of autonomous control of growth and/or differentiation state in the progeny Biochemical and biological evidence for most of these steps in various transformed cells makes it possible to analyze autocrine control as a multifaceted process. This process depends on tumor cellularity and histoarchitecture, on time and on external influences on secretion of autocrine mediators (e.g., estrogens in estrogen-dependent breast cancer). We review the quantitative aspects of experimental evidence for autocrine control in tumors and examine the phenomenological and some mechanistic concepts in creating integrative, quantitative, and experimentally verifiable mathematical models of autocrine regulation.

AB - Autocrine regulation is defined as a mechanism of self-control in growth and differentiation; this mode of regulation among histologically homologous cells is mediated humorally. Autocrine mechanisms involve: 1. Autonomously controlled production and secretion of autocrine mediators. 2. Distribution of autocrine mediators among cells. 3. Expression by cells of functional receptors for autocrine mediators. 4. Transduction and intracellular integration of signals mediated by autocrine mediators. 5. Growth response. 6. Maintenance of autonomous control of growth and/or differentiation state in the progeny Biochemical and biological evidence for most of these steps in various transformed cells makes it possible to analyze autocrine control as a multifaceted process. This process depends on tumor cellularity and histoarchitecture, on time and on external influences on secretion of autocrine mediators (e.g., estrogens in estrogen-dependent breast cancer). We review the quantitative aspects of experimental evidence for autocrine control in tumors and examine the phenomenological and some mechanistic concepts in creating integrative, quantitative, and experimentally verifiable mathematical models of autocrine regulation.

UR - http://www.scopus.com/inward/record.url?scp=0025580202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025580202&partnerID=8YFLogxK

M3 - Article

C2 - 1965422

AN - SCOPUS:0025580202

VL - 2

SP - 53

EP - 73

JO - Critical Reviews in Oncogenesis

JF - Critical Reviews in Oncogenesis

SN - 0893-9675

IS - 1

ER -