Quantitative analysis of fetal pulmonary vasculature by 3-dimensional power Doppler ultrasonography in isolated congenital diaphragmatic hernia

Rodrigo Ruano, Marie Cécile Aubry, Bruno Barthe, Delphine Mitanchez, Yves Dumez, Alexandra Benachi

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Objective: The purpose of this study was to evaluate the potential of 3-dimensional (3D) power Doppler imaging to predict neonatal outcome and pulmonary arterial hypertension (PAH) in congenital diaphragmatic hernia (CDH). Study design: In this prospective observational study, 3D-power Doppler ultrasonography was performed in 21 cases with isolated CDH between 23 and 33 weeks of gestation and in 58 controls between 20 and 40 weeks. Using the same preestablished settings for all cases, power Doppler was applied to each lung, and fetal lung volumes (FLV) were estimated using the rotational technique. The 3D power Doppler histogram was used to determine the vascular indices, which were plotted against gestational age and compared with neonatal outcome, PAH, gestational age, and FLV. Results: Fetal pulmonary vascular indices showed a constant distribution throughout gestation, being significantly lower in cases with CDH than in controls (P < .001). Among CDH cases, the vascular indices were significantly lower in fetuses who died (P < .05), and in fetuses with neonatal PAH (P < .05). The severity of neonatal PAH was also associated with a progressive reduction in prenatal vascular indices (P < .05). All vascular indices correlated with o/e-FLV, but not with gestational age. Conclusion: All vascular indices seem to be constant throughout gestation. In isolated CDH, perinatal outcome and postnatal PAH can be predicted using the vascular indices assessed by 3D power Doppler histogram.

Original languageEnglish (US)
Pages (from-to)1720-1728
Number of pages9
JournalAmerican Journal of Obstetrics and Gynecology
Volume195
Issue number6
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

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Doppler Ultrasonography
Blood Vessels
Pulmonary Hypertension
Lung
Gestational Age
Pregnancy
Fetus
Congenital Diaphragmatic Hernias
Observational Studies
Prospective Studies

Keywords

  • Congenital diaphragmatic hernia
  • Fetal lung
  • Fetal malformation
  • Pulmonary hypoplasia
  • Three-dimensional power Doppler ultrasound

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Quantitative analysis of fetal pulmonary vasculature by 3-dimensional power Doppler ultrasonography in isolated congenital diaphragmatic hernia. / Ruano, Rodrigo; Aubry, Marie Cécile; Barthe, Bruno; Mitanchez, Delphine; Dumez, Yves; Benachi, Alexandra.

In: American Journal of Obstetrics and Gynecology, Vol. 195, No. 6, 01.12.2006, p. 1720-1728.

Research output: Contribution to journalArticle

Ruano, Rodrigo ; Aubry, Marie Cécile ; Barthe, Bruno ; Mitanchez, Delphine ; Dumez, Yves ; Benachi, Alexandra. / Quantitative analysis of fetal pulmonary vasculature by 3-dimensional power Doppler ultrasonography in isolated congenital diaphragmatic hernia. In: American Journal of Obstetrics and Gynecology. 2006 ; Vol. 195, No. 6. pp. 1720-1728.
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