Quantitation of 14-3-3 and neuron-specific enolase proteins in CSF in Creutzfeldt-Jakob disease

Allen J. Aksamit, Carol M. Preissner, Henry A. Homburger

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

CSF 14-3-3 and neuron-specific enolase (NSE) proteins were quantitated from patients who had Creutzfeldt-Jakob disease (CJD) or other rapidly dementing disorders initially considered to be CJD. Thirty-one patients were diagnosed as having CJD among 152 studied. CSF 14-3-3 values more than 8 ng/mL correlated with CJD. CSF NSE values less than 30 ng/mL and 14-3-3 values less than 8 ng/mL made a diagnosis of CJD unlikely, but did not exclude it.

Original languageEnglish (US)
Pages (from-to)728-730
Number of pages3
JournalNeurology
Volume57
Issue number4
DOIs
StatePublished - Aug 28 2001

ASJC Scopus subject areas

  • Clinical Neurology

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