Quantitation of 14-3-3 and neuron-specific enolase proteins in CSF in Creutzfeldt-Jakob disease

Allen Jr. Aksamit, Carol M. Preissner, Henry A. Homburger

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

CSF 14-3-3 and neuron-specific enolase (NSE) proteins were quantitated from patients who had Creutzfeldt-Jakob disease (CJD) or other rapidly dementing disorders initially considered to be CJD. Thirty-one patients were diagnosed as having CJD among 152 studied. CSF 14-3-3 values more than 8 ng/mL correlated with CJD. CSF NSE values less than 30 ng/mL and 14-3-3 values less than 8 ng/mL made a diagnosis of CJD unlikely, but did not exclude it.

Original languageEnglish (US)
Pages (from-to)728-730
Number of pages3
JournalNeurology
Volume57
Issue number4
DOIs
StatePublished - Aug 28 2001

Fingerprint

Creutzfeldt-Jakob Syndrome
Phosphopyruvate Hydratase
Proteins

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Quantitation of 14-3-3 and neuron-specific enolase proteins in CSF in Creutzfeldt-Jakob disease. / Aksamit, Allen Jr.; Preissner, Carol M.; Homburger, Henry A.

In: Neurology, Vol. 57, No. 4, 28.08.2001, p. 728-730.

Research output: Contribution to journalArticle

Aksamit, Allen Jr. ; Preissner, Carol M. ; Homburger, Henry A. / Quantitation of 14-3-3 and neuron-specific enolase proteins in CSF in Creutzfeldt-Jakob disease. In: Neurology. 2001 ; Vol. 57, No. 4. pp. 728-730.
@article{fe2d5f93180042abb0dea676ad45c339,
title = "Quantitation of 14-3-3 and neuron-specific enolase proteins in CSF in Creutzfeldt-Jakob disease",
abstract = "CSF 14-3-3 and neuron-specific enolase (NSE) proteins were quantitated from patients who had Creutzfeldt-Jakob disease (CJD) or other rapidly dementing disorders initially considered to be CJD. Thirty-one patients were diagnosed as having CJD among 152 studied. CSF 14-3-3 values more than 8 ng/mL correlated with CJD. CSF NSE values less than 30 ng/mL and 14-3-3 values less than 8 ng/mL made a diagnosis of CJD unlikely, but did not exclude it.",
author = "Aksamit, {Allen Jr.} and Preissner, {Carol M.} and Homburger, {Henry A.}",
year = "2001",
month = "8",
day = "28",
doi = "10.1212/WNL.57.4.728",
language = "English (US)",
volume = "57",
pages = "728--730",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Quantitation of 14-3-3 and neuron-specific enolase proteins in CSF in Creutzfeldt-Jakob disease

AU - Aksamit, Allen Jr.

AU - Preissner, Carol M.

AU - Homburger, Henry A.

PY - 2001/8/28

Y1 - 2001/8/28

N2 - CSF 14-3-3 and neuron-specific enolase (NSE) proteins were quantitated from patients who had Creutzfeldt-Jakob disease (CJD) or other rapidly dementing disorders initially considered to be CJD. Thirty-one patients were diagnosed as having CJD among 152 studied. CSF 14-3-3 values more than 8 ng/mL correlated with CJD. CSF NSE values less than 30 ng/mL and 14-3-3 values less than 8 ng/mL made a diagnosis of CJD unlikely, but did not exclude it.

AB - CSF 14-3-3 and neuron-specific enolase (NSE) proteins were quantitated from patients who had Creutzfeldt-Jakob disease (CJD) or other rapidly dementing disorders initially considered to be CJD. Thirty-one patients were diagnosed as having CJD among 152 studied. CSF 14-3-3 values more than 8 ng/mL correlated with CJD. CSF NSE values less than 30 ng/mL and 14-3-3 values less than 8 ng/mL made a diagnosis of CJD unlikely, but did not exclude it.

UR - http://www.scopus.com/inward/record.url?scp=0035964161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035964161&partnerID=8YFLogxK

U2 - 10.1212/WNL.57.4.728

DO - 10.1212/WNL.57.4.728

M3 - Article

C2 - 11524493

AN - SCOPUS:0035964161

VL - 57

SP - 728

EP - 730

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 4

ER -