TY - JOUR
T1 - Quantifying Tumor Stiffness With Magnetic Resonance Elastography
T2 - The Role of Mechanical Properties for Detection, Characterization, and Treatment Stratification in Oncology
AU - Pepin, Kay M.
AU - McGee, Kiaran Patrick
PY - 2018/10/1
Y1 - 2018/10/1
N2 - The viscoelastic properties of tissue are significantly altered with the development of tumors and these alterations can be assessed with magnetic resonance elastography (MRE). Accurate detection and characterization of malignant and benign lesions can be obtained by quantifying tumor stiffness, improving the specificity and diagnostic accuracy of conventional magnetic resonance imaging. Furthermore, MRE can be used to stratify patients for treatment based on risk of normal tissue toxicity and surgical considerations including consistency and adherence of the tumor to surrounding structures. MRE is a reliable reproducible technique demonstrated in studies that include both patients with cancer and normal volunteers, and an average technical failure rate of <1%. The addition of MRE into a multiparametric magnetic resonance imaging assessment may improve the diagnosis and treatment of cancer.
AB - The viscoelastic properties of tissue are significantly altered with the development of tumors and these alterations can be assessed with magnetic resonance elastography (MRE). Accurate detection and characterization of malignant and benign lesions can be obtained by quantifying tumor stiffness, improving the specificity and diagnostic accuracy of conventional magnetic resonance imaging. Furthermore, MRE can be used to stratify patients for treatment based on risk of normal tissue toxicity and surgical considerations including consistency and adherence of the tumor to surrounding structures. MRE is a reliable reproducible technique demonstrated in studies that include both patients with cancer and normal volunteers, and an average technical failure rate of <1%. The addition of MRE into a multiparametric magnetic resonance imaging assessment may improve the diagnosis and treatment of cancer.
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U2 - 10.1097/RMR.0000000000000181
DO - 10.1097/RMR.0000000000000181
M3 - Article
C2 - 30289830
AN - SCOPUS:85054427375
VL - 27
SP - 353
EP - 362
JO - Topics in Magnetic Resonance Imaging
JF - Topics in Magnetic Resonance Imaging
SN - 0899-3459
IS - 5
ER -