Quantification of sweat gland volume and innervation in neuropathy: Correlation with thermoregulatory sweat testing

Adam Loavenbruck, Gwen Wendelschaefer-Crabbe, Paola Sandroni, William R. Kennedy

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Introduction: No study has correlated thermoregulatory sweat testing (TST) with histopathologic study of sweat glands (SGs) and SG nerve fibers (SGNFs). Methods: We studied 10 neuropathy patients in whom anhidrosis was found by TST and 10 matched controls. Skin biopsies were taken from both anhidrotic and sweating skin and immunohistochemical staining was done for nerves and basement membrane. For each biopsy, total tissue volume, total SG volume, and total SGNF length were measured. SGNF length per biopsy volume, SG volume per biopsy volume (SG%), and SGNF length per SG volume were calculated. Results: SGNF length per biopsy volume was reduced in anhidrotic site biopsies of patients compared with controls. SG% was decreased and SGNF length per SG volume increased in patients compared with controls. Conclusions: The results suggest a concomitant loss of SG volume and SGNF length in neuropathy, with greater loss of SGNFs in anhidrotic skin, possibly exceeding collateral reinnervation.

Original languageEnglish (US)
Pages (from-to)528-534
Number of pages7
JournalMuscle and Nerve
Volume50
Issue number4
DOIs
StatePublished - Oct 1 2014

Keywords

  • Neuropathy
  • Skin biopsy
  • Small fiber neuropathy
  • Sweat gland nerve fibers
  • Sweat testing

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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