Quantification of myocardial perfusion by MRI after coronary occlusion

Jean Paul M. Vallée; H. Dirk Sostman; James R. MacFall; Timothy R. DeGrado; Jian Zhang; Laurent Sebbag; Fred R. Cobb; Ted Wheeler; Larry W. Hedlund; Timothy G. Turkington; Charles E. Spritzer; R. Edward Coleman

doi:10.1002/mrm.1910400215

Quantification of myocardial perfusion by MRI after coronary occlusion

Jean Paul M. Vallée, H. Dirk Sostman, James R. MacFall, Timothy R. DeGrado, Jian Zhang, Laurent Sebbag, Fred R. Cobb, Ted Wheeler, Larry W. Hedlund, Timothy G. Turkington, Charles E. Spritzer, R. Edward Coleman

Radiology

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

The objectives of this study were to define the relationship between the first order constant of Gd-DTPA transfer (K1) and the myocardial blood flow (MBF) at rest and to compare it with an equivalent relationship obtained for positron emission tomography (PET). In a canine model of permanent coronary occlusion (n = 4), myocardial and blood time concentration curves obtained by ¹³N-ammonia PET and Gd-DTPA-enhanced MRI were fitted by a one-compartment model to determine K1. A linear relationship was observed between MRI- derived K1 and MBF measured by microspheres (K1 = 0.88 x flow -0.015, R = 0.95), which compares favorably with the equivalent relationship derived from PET (K1 = 0.74 x flow +0.16, R = 0.88). The results of this preliminary study suggest that, at rest and distal to a permanently occluded coronary artery, myocardial perfusion quantification by MRI is possible and can challenge PET.

Original language	English (US)
Pages (from-to)	287-297
Number of pages	11
Journal	Magnetic Resonance in Medicine
Volume	40
Issue number	2
DOIs	https://doi.org/10.1002/mrm.1910400215
State	Published - Aug 1998

Keywords

Blood flow
Magnetic resonance imaging
Myocardial infarction
Radioisotopes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/mrm.1910400215

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title = "Quantification of myocardial perfusion by MRI after coronary occlusion",

abstract = "The objectives of this study were to define the relationship between the first order constant of Gd-DTPA transfer (K1) and the myocardial blood flow (MBF) at rest and to compare it with an equivalent relationship obtained for positron emission tomography (PET). In a canine model of permanent coronary occlusion (n = 4), myocardial and blood time concentration curves obtained by 13N-ammonia PET and Gd-DTPA-enhanced MRI were fitted by a one-compartment model to determine K1. A linear relationship was observed between MRI- derived K1 and MBF measured by microspheres (K1 = 0.88 x flow -0.015, R = 0.95), which compares favorably with the equivalent relationship derived from PET (K1 = 0.74 x flow +0.16, R = 0.88). The results of this preliminary study suggest that, at rest and distal to a permanently occluded coronary artery, myocardial perfusion quantification by MRI is possible and can challenge PET.",

keywords = "Blood flow, Magnetic resonance imaging, Myocardial infarction, Radioisotopes",

author = "Vall{\'e}e, {Jean Paul M.} and Sostman, {H. Dirk} and MacFall, {James R.} and DeGrado, {Timothy R.} and Jian Zhang and Laurent Sebbag and Cobb, {Fred R.} and Ted Wheeler and Hedlund, {Larry W.} and Turkington, {Timothy G.} and Spritzer, {Charles E.} and Coleman, {R. Edward}",

year = "1998",

month = aug,

doi = "10.1002/mrm.1910400215",

language = "English (US)",

volume = "40",

pages = "287--297",

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AU - Vallée, Jean Paul M.

AU - Sostman, H. Dirk

AU - MacFall, James R.

AU - DeGrado, Timothy R.

AU - Zhang, Jian

AU - Sebbag, Laurent

AU - Cobb, Fred R.

AU - Wheeler, Ted

AU - Hedlund, Larry W.

AU - Turkington, Timothy G.

AU - Spritzer, Charles E.

AU - Coleman, R. Edward

PY - 1998/8

Y1 - 1998/8

N2 - The objectives of this study were to define the relationship between the first order constant of Gd-DTPA transfer (K1) and the myocardial blood flow (MBF) at rest and to compare it with an equivalent relationship obtained for positron emission tomography (PET). In a canine model of permanent coronary occlusion (n = 4), myocardial and blood time concentration curves obtained by 13N-ammonia PET and Gd-DTPA-enhanced MRI were fitted by a one-compartment model to determine K1. A linear relationship was observed between MRI- derived K1 and MBF measured by microspheres (K1 = 0.88 x flow -0.015, R = 0.95), which compares favorably with the equivalent relationship derived from PET (K1 = 0.74 x flow +0.16, R = 0.88). The results of this preliminary study suggest that, at rest and distal to a permanently occluded coronary artery, myocardial perfusion quantification by MRI is possible and can challenge PET.

AB - The objectives of this study were to define the relationship between the first order constant of Gd-DTPA transfer (K1) and the myocardial blood flow (MBF) at rest and to compare it with an equivalent relationship obtained for positron emission tomography (PET). In a canine model of permanent coronary occlusion (n = 4), myocardial and blood time concentration curves obtained by 13N-ammonia PET and Gd-DTPA-enhanced MRI were fitted by a one-compartment model to determine K1. A linear relationship was observed between MRI- derived K1 and MBF measured by microspheres (K1 = 0.88 x flow -0.015, R = 0.95), which compares favorably with the equivalent relationship derived from PET (K1 = 0.74 x flow +0.16, R = 0.88). The results of this preliminary study suggest that, at rest and distal to a permanently occluded coronary artery, myocardial perfusion quantification by MRI is possible and can challenge PET.

KW - Blood flow

KW - Magnetic resonance imaging

KW - Myocardial infarction

KW - Radioisotopes

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Quantification of myocardial perfusion by MRI after coronary occlusion

Abstract

Keywords

ASJC Scopus subject areas

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