Quantification of global and regional renal blood flow with electron beam computed tomography

Lilach O Lerman, Malcolm R. Bell, Vicente Lahera, John A. Rumberger, Patrick F. Sheedy, Alberto Sanchez Fueyo, J. Carlos Romero

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33 Scopus citations


Alterations in renal blood flow distribution may occur in a variety of pathophysiologic situations; however, quantification of global and regional renal blood flows has been limited because of the lack of reliable, noninvasive techniques. To determine the feasibility of flow measurements with electron-beam computed tomography (EBCT), six anesthetized dogs were scanned by EBCT during basal conditions, after renal vasodilation, and at recovery. Flow (mL/min/cm3 tissue) was calculated from EBCT-derived time-density curves using three different algorithms and compared with simultaneously obtained electromagnetic flow (EMF) probe measurements after indexing to EBCT-derived renal volume. EBCT-determined flow correlated well with EMF measurements regardless of the algorithm used. An algorithm using the area under the time-density curve was concluded to be the most suitable for calculation of renal blood flow; it correlated with EMF as EBCT flow = 44.5 + 1.05 EMF (r = 0.885, SEE = 31.2 mL/min, P < .0001). Consistent overestimation of flow by EBCT resulted probably from retention of contrast media in the renal parenchyma. EMF showed an increase of 20 ± 10% in renal blood flow after vasodilation. EBCT-derived global, cortical, and medullary flows increased by 33.8 ± 10.3%, 24.8 ± 17.8%, and 99.0 ± 73.8%, respectively. In conclusion, EBCT was found feasible for credible quantitation of renal blood flow in the physiologic range studied.

Original languageEnglish (US)
Pages (from-to)829-837
Number of pages9
JournalAmerican Journal of Hypertension
Issue number9 PART 1
StatePublished - Sep 1994



  • cortical blood flow
  • electron-beam computed tomography
  • medullary blood flow
  • Renal blood flow

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lerman, L. O., Bell, M. R., Lahera, V., Rumberger, J. A., Sheedy, P. F., Fueyo, A. S., & Romero, J. C. (1994). Quantification of global and regional renal blood flow with electron beam computed tomography. American Journal of Hypertension, 7(9 PART 1), 829-837.