Quantification of global and regional renal blood flow with electron beam computed tomography

Lilach O. Lerman; Malcolm R. Bell; Vicente Lahera; John A. Rumberger; Patrick F. Sheedy; Alberto Sanchez Fueyo

doi:10.1093/ajh/7.9.829

Quantification of global and regional renal blood flow with electron beam computed tomography

Lilach O. Lerman, Malcolm R. Bell, Vicente Lahera, John A. Rumberger, Patrick F. Sheedy, Alberto Sanchez Fueyo

Nephrology and Hypertension

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Alterations in renal blood flow distribution may occur in a variety of pathophysiologic situations; however, quantification of global and regional renal blood flows has been limited because of the lack of reliable, noninvasive techniques. To determine the feasibility of flow measurements with electron-beam computed tomography (EBCT), six anesthetized dogs were scanned by EBCT during basal conditions, after renal vasodilation, and at recovery. Flow (mL/min/cm³ tissue) was calculated from EBCT-derived time-density curves using three different algorithms and compared with simultaneously obtained electromagnetic flow (EMF) probe measurements after indexing to EBCT-derived renal volume. EBCT-determined flow correlated well with EMF measurements regardless of the algorithm used. An algorithm using the area under the time-density curve was concluded to be the most suitable for calculation of renal blood flow; it correlated with EMF as EBCT flow = 44.5 + 1.05 EMF (r = 0.885, SEE = 31.2 mL/min, P <.0001). Consistent overestimation of flow by EBCT resulted probably from retention of contrast media in the renal parenchyma. EMF showed an increase of 20 ± 10% in renal blood flow after vasodilation. EBCT-derived global, cortical, and medullary flows increased by 33.8 ± 10.3%, 24.8 ± 17.8%, and 99.0 ± 73.8%, respectively. In conclusion, EBCT was found feasible for credible quantitation of renal blood flow in the physiologic range studied. Am J Hypertens 1994;7:829–837.

Original language	English (US)
Pages (from-to)	829-837
Number of pages	9
Journal	American journal of hypertension
Volume	7
Issue number	9
DOIs	https://doi.org/10.1093/ajh/7.9.829
State	Published - Nov 1994

Keywords

Cortical blood flow
Electron-beam computed tomography
Medullary blood flow
Renal blood flow

ASJC Scopus subject areas

Internal Medicine

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10.1093/ajh/7.9.829

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@article{5a414e32fd1946dba204f4d8de014864,

title = "Quantification of global and regional renal blood flow with electron beam computed tomography",

abstract = "Alterations in renal blood flow distribution may occur in a variety of pathophysiologic situations; however, quantification of global and regional renal blood flows has been limited because of the lack of reliable, noninvasive techniques. To determine the feasibility of flow measurements with electron-beam computed tomography (EBCT), six anesthetized dogs were scanned by EBCT during basal conditions, after renal vasodilation, and at recovery. Flow (mL/min/cm3 tissue) was calculated from EBCT-derived time-density curves using three different algorithms and compared with simultaneously obtained electromagnetic flow (EMF) probe measurements after indexing to EBCT-derived renal volume. EBCT-determined flow correlated well with EMF measurements regardless of the algorithm used. An algorithm using the area under the time-density curve was concluded to be the most suitable for calculation of renal blood flow; it correlated with EMF as EBCT flow = 44.5 + 1.05 EMF (r = 0.885, SEE = 31.2 mL/min, P <.0001). Consistent overestimation of flow by EBCT resulted probably from retention of contrast media in the renal parenchyma. EMF showed an increase of 20 ± 10% in renal blood flow after vasodilation. EBCT-derived global, cortical, and medullary flows increased by 33.8 ± 10.3%, 24.8 ± 17.8%, and 99.0 ± 73.8%, respectively. In conclusion, EBCT was found feasible for credible quantitation of renal blood flow in the physiologic range studied. Am J Hypertens 1994;7:829–837.",

keywords = "Cortical blood flow, Electron-beam computed tomography, Medullary blood flow, Renal blood flow",

author = "Lerman, {Lilach O.} and Bell, {Malcolm R.} and Vicente Lahera and Rumberger, {John A.} and Sheedy, {Patrick F.} and Fueyo, {Alberto Sanchez}",

note = "Funding Information: Received February 4, 1994. Accepted June 20, 1994. From the Department of Physiology and Biophysics (LOL, VL, ASF, JCR), the Division of Cardiovascular Diseases and Internal Medicine (MRB, JAR), and the Department of Radiology (PFS), Mayo Clinic and Foundation, Rochester, Minnesota. This study was supported by grant HL16496 from the National Institutes of Health. Dr. Lahera is now at the Department de Fisiologia, Facultad de Medicina, Universitad Complutense, 28040 Madrid, Spain. Address correspondence and reprint requests to Dr. J. Carlos Romero, Department of Physiology and Biophysics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.",

year = "1994",

month = nov,

doi = "10.1093/ajh/7.9.829",

language = "English (US)",

volume = "7",

pages = "829--837",

journal = "American journal of hypertension",

issn = "0895-7061",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Quantification of global and regional renal blood flow with electron beam computed tomography

AU - Lerman, Lilach O.

AU - Bell, Malcolm R.

AU - Lahera, Vicente

AU - Rumberger, John A.

AU - Sheedy, Patrick F.

AU - Fueyo, Alberto Sanchez

N1 - Funding Information: Received February 4, 1994. Accepted June 20, 1994. From the Department of Physiology and Biophysics (LOL, VL, ASF, JCR), the Division of Cardiovascular Diseases and Internal Medicine (MRB, JAR), and the Department of Radiology (PFS), Mayo Clinic and Foundation, Rochester, Minnesota. This study was supported by grant HL16496 from the National Institutes of Health. Dr. Lahera is now at the Department de Fisiologia, Facultad de Medicina, Universitad Complutense, 28040 Madrid, Spain. Address correspondence and reprint requests to Dr. J. Carlos Romero, Department of Physiology and Biophysics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

PY - 1994/11

Y1 - 1994/11

N2 - Alterations in renal blood flow distribution may occur in a variety of pathophysiologic situations; however, quantification of global and regional renal blood flows has been limited because of the lack of reliable, noninvasive techniques. To determine the feasibility of flow measurements with electron-beam computed tomography (EBCT), six anesthetized dogs were scanned by EBCT during basal conditions, after renal vasodilation, and at recovery. Flow (mL/min/cm3 tissue) was calculated from EBCT-derived time-density curves using three different algorithms and compared with simultaneously obtained electromagnetic flow (EMF) probe measurements after indexing to EBCT-derived renal volume. EBCT-determined flow correlated well with EMF measurements regardless of the algorithm used. An algorithm using the area under the time-density curve was concluded to be the most suitable for calculation of renal blood flow; it correlated with EMF as EBCT flow = 44.5 + 1.05 EMF (r = 0.885, SEE = 31.2 mL/min, P <.0001). Consistent overestimation of flow by EBCT resulted probably from retention of contrast media in the renal parenchyma. EMF showed an increase of 20 ± 10% in renal blood flow after vasodilation. EBCT-derived global, cortical, and medullary flows increased by 33.8 ± 10.3%, 24.8 ± 17.8%, and 99.0 ± 73.8%, respectively. In conclusion, EBCT was found feasible for credible quantitation of renal blood flow in the physiologic range studied. Am J Hypertens 1994;7:829–837.

AB - Alterations in renal blood flow distribution may occur in a variety of pathophysiologic situations; however, quantification of global and regional renal blood flows has been limited because of the lack of reliable, noninvasive techniques. To determine the feasibility of flow measurements with electron-beam computed tomography (EBCT), six anesthetized dogs were scanned by EBCT during basal conditions, after renal vasodilation, and at recovery. Flow (mL/min/cm3 tissue) was calculated from EBCT-derived time-density curves using three different algorithms and compared with simultaneously obtained electromagnetic flow (EMF) probe measurements after indexing to EBCT-derived renal volume. EBCT-determined flow correlated well with EMF measurements regardless of the algorithm used. An algorithm using the area under the time-density curve was concluded to be the most suitable for calculation of renal blood flow; it correlated with EMF as EBCT flow = 44.5 + 1.05 EMF (r = 0.885, SEE = 31.2 mL/min, P <.0001). Consistent overestimation of flow by EBCT resulted probably from retention of contrast media in the renal parenchyma. EMF showed an increase of 20 ± 10% in renal blood flow after vasodilation. EBCT-derived global, cortical, and medullary flows increased by 33.8 ± 10.3%, 24.8 ± 17.8%, and 99.0 ± 73.8%, respectively. In conclusion, EBCT was found feasible for credible quantitation of renal blood flow in the physiologic range studied. Am J Hypertens 1994;7:829–837.

KW - Cortical blood flow

KW - Electron-beam computed tomography

KW - Medullary blood flow

KW - Renal blood flow

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U2 - 10.1093/ajh/7.9.829

DO - 10.1093/ajh/7.9.829

M3 - Article

C2 - 7811442

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SN - 0895-7061

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EP - 837

JO - American journal of hypertension

JF - American journal of hypertension

IS - 9

ER -

Quantification of global and regional renal blood flow with electron beam computed tomography

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