TY - JOUR
T1 - Quantification of global and regional renal blood flow with electron beam computed tomography
AU - Lerman, Lilach O.
AU - Bell, Malcolm R.
AU - Lahera, Vicente
AU - Rumberger, John A.
AU - Sheedy, Patrick F.
AU - Fueyo, Alberto Sanchez
PY - 1994/11
Y1 - 1994/11
N2 - Alterations in renal blood flow distribution may occur in a variety of pathophysiologic situations; however, quantification of global and regional renal blood flows has been limited because of the lack of reliable, noninvasive techniques. To determine the feasibility of flow measurements with electron-beam computed tomography (EBCT), six anesthetized dogs were scanned by EBCT during basal conditions, after renal vasodilation, and at recovery. Flow (mL/min/cm3 tissue) was calculated from EBCT-derived time-density curves using three different algorithms and compared with simultaneously obtained electromagnetic flow (EMF) probe measurements after indexing to EBCT-derived renal volume. EBCT-determined flow correlated well with EMF measurements regardless of the algorithm used. An algorithm using the area under the time-density curve was concluded to be the most suitable for calculation of renal blood flow; it correlated with EMF as EBCT flow = 44.5 + 1.05 EMF (r = 0.885, SEE = 31.2 mL/min, P <.0001). Consistent overestimation of flow by EBCT resulted probably from retention of contrast media in the renal parenchyma. EMF showed an increase of 20 ± 10% in renal blood flow after vasodilation. EBCT-derived global, cortical, and medullary flows increased by 33.8 ± 10.3%, 24.8 ± 17.8%, and 99.0 ± 73.8%, respectively. In conclusion, EBCT was found feasible for credible quantitation of renal blood flow in the physiologic range studied. Am J Hypertens 1994;7:829–837.
AB - Alterations in renal blood flow distribution may occur in a variety of pathophysiologic situations; however, quantification of global and regional renal blood flows has been limited because of the lack of reliable, noninvasive techniques. To determine the feasibility of flow measurements with electron-beam computed tomography (EBCT), six anesthetized dogs were scanned by EBCT during basal conditions, after renal vasodilation, and at recovery. Flow (mL/min/cm3 tissue) was calculated from EBCT-derived time-density curves using three different algorithms and compared with simultaneously obtained electromagnetic flow (EMF) probe measurements after indexing to EBCT-derived renal volume. EBCT-determined flow correlated well with EMF measurements regardless of the algorithm used. An algorithm using the area under the time-density curve was concluded to be the most suitable for calculation of renal blood flow; it correlated with EMF as EBCT flow = 44.5 + 1.05 EMF (r = 0.885, SEE = 31.2 mL/min, P <.0001). Consistent overestimation of flow by EBCT resulted probably from retention of contrast media in the renal parenchyma. EMF showed an increase of 20 ± 10% in renal blood flow after vasodilation. EBCT-derived global, cortical, and medullary flows increased by 33.8 ± 10.3%, 24.8 ± 17.8%, and 99.0 ± 73.8%, respectively. In conclusion, EBCT was found feasible for credible quantitation of renal blood flow in the physiologic range studied. Am J Hypertens 1994;7:829–837.
KW - Cortical blood flow
KW - Electron-beam computed tomography
KW - Medullary blood flow
KW - Renal blood flow
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U2 - 10.1093/ajh/7.9.829
DO - 10.1093/ajh/7.9.829
M3 - Article
C2 - 7811442
AN - SCOPUS:0028116003
VL - 7
SP - 829
EP - 837
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 9
ER -