TY - JOUR
T1 - Quantification of diet quality utilizing the rapid eating assessment for participants-shortened version in bipolar disorder
T2 - Implications for prospective depression and cardiometabolic studies
AU - Gardea-Resendez, Manuel
AU - Winham, Stacey J.
AU - Romo-Nava, Francisco
AU - Cuellar-Barboza, Alfredo
AU - Clark, Matthew M.
AU - Andreazza, Ana Cristina
AU - Cabello-Arreola, Alejandra
AU - Veldic, Marin
AU - Bond, David J.
AU - Singh, Balwinder
AU - Prieto, Miguel L.
AU - Nunez, Nicolas A.
AU - Betcher, Hannah
AU - Moore, Katherine M.
AU - Blom, Thomas
AU - Colby, Colin
AU - Pendegraft, Richard S.
AU - Kelpin, Sydney S.
AU - Ozerdem, Aysegul
AU - Miola, Alessandro
AU - De Filippis, Eleanna
AU - Biernacka, Joanna M.
AU - McElroy, Susan L.
AU - Frye, Mark A.
N1 - Publisher Copyright:
© 2022
PY - 2022/8/1
Y1 - 2022/8/1
N2 - Objectives: Recognizing bipolar disorder as a multi-system metabolic condition driven, in part, by binge eating behavior and atypical depressive symptoms, this study aimed to quantify diet quality and evaluate clinical correlates in a bipolar disorder cohort. Methods: Participants from the Mayo Clinic Bipolar Disorder Biobank (n = 734) completed the Rapid Eating Assessment for Participants – Shortened version (REAP-S) to determine diet quality. The average REAP-S score for a U.S. omnivorous diet is 32 (range 13 to 39) with higher scores indicating healthier diet. Demographic variables were collected in a standardized clinical questionnaire. Depressive symptoms were assessed by the Bipolar Inventory of Symptoms Scale. Cardiometabolic variables were retrieved from the electronic health record. Associations between continuous variables and REAP-S scores (total, ‘healthy foods’ and ‘avoidance of unhealthy foods’) were assessed using linear regression. Results: Overall, our sample had a mean REAP-S score of 27.6 (4.9), suggestive of a lower diet quality than the average general population in the US. There was a significant inverse relationship between mean REAP-S lower scores with increased BMI, waist circumference, disordered eating and depression. All these associations were significantly stronger in female participants. Limitations: EHR cross-sectional data. Conclusions: Our data suggest unhealthy diet quality in bipolar disorder is associated with depression, obesity and cardiometabolic abnormalities. Additional work is encouraged to prospectively track mood and diet quality to further understand the bidirectional relationship and clarify if dietary interventions can positively impact mood. Further delineating potential sex differences in diet quality and depression may provide greater appreciation of modifiable risk factors for future cardiometabolic burden.
AB - Objectives: Recognizing bipolar disorder as a multi-system metabolic condition driven, in part, by binge eating behavior and atypical depressive symptoms, this study aimed to quantify diet quality and evaluate clinical correlates in a bipolar disorder cohort. Methods: Participants from the Mayo Clinic Bipolar Disorder Biobank (n = 734) completed the Rapid Eating Assessment for Participants – Shortened version (REAP-S) to determine diet quality. The average REAP-S score for a U.S. omnivorous diet is 32 (range 13 to 39) with higher scores indicating healthier diet. Demographic variables were collected in a standardized clinical questionnaire. Depressive symptoms were assessed by the Bipolar Inventory of Symptoms Scale. Cardiometabolic variables were retrieved from the electronic health record. Associations between continuous variables and REAP-S scores (total, ‘healthy foods’ and ‘avoidance of unhealthy foods’) were assessed using linear regression. Results: Overall, our sample had a mean REAP-S score of 27.6 (4.9), suggestive of a lower diet quality than the average general population in the US. There was a significant inverse relationship between mean REAP-S lower scores with increased BMI, waist circumference, disordered eating and depression. All these associations were significantly stronger in female participants. Limitations: EHR cross-sectional data. Conclusions: Our data suggest unhealthy diet quality in bipolar disorder is associated with depression, obesity and cardiometabolic abnormalities. Additional work is encouraged to prospectively track mood and diet quality to further understand the bidirectional relationship and clarify if dietary interventions can positively impact mood. Further delineating potential sex differences in diet quality and depression may provide greater appreciation of modifiable risk factors for future cardiometabolic burden.
KW - Bipolar depression
KW - Bipolar disorder
KW - Cardiometabolic markers
KW - Diet quality
KW - Obesity
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U2 - 10.1016/j.jad.2022.05.037
DO - 10.1016/j.jad.2022.05.037
M3 - Article
C2 - 35545158
AN - SCOPUS:85129962850
SN - 0165-0327
VL - 310
SP - 150
EP - 155
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -