Quantification of coronary calcification using high-resolution photon-counting-detector CT and an image domain denoising algorithm

Patrick D. Vanmeter, Jeffery Marsh, Kishore Rajendran, Shuai Leng, Cynthia McCollough

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Coronary artery calcification is an important indicator of coronary disease. Accurate volume quantification of coronary calcification using computed tomography (CT) is challenging due to calcium blooming. In this study, ex-vivo coronary specimens were scanned on an investigational photon-counting detector (PCD) CT scanner and the estimated coronary calcification volume were compared with a conventional energy-integrating detector (EID) CT. An image-based denoising algorithm was applied to the PCD-CT images to achieve similar noise levels as EID-CT. Calcifications were segmented to estimate the volume, with micro-CT images of the same calcifications serving as reference. PCD-CT images showed reduced calcium blooming artifacts.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2022
Subtitle of host publicationPhysics of Medical Imaging
EditorsWei Zhao, Lifeng Yu
PublisherSPIE
ISBN (Electronic)9781510649378
DOIs
StatePublished - 2022
EventMedical Imaging 2022: Physics of Medical Imaging - Virtual, Online
Duration: Mar 21 2022Mar 27 2022

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume12031
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2022: Physics of Medical Imaging
CityVirtual, Online
Period3/21/223/27/22

Keywords

  • calcium quantification
  • coronary artery disease
  • coronary calcifications
  • image domain denoising
  • Photon counting detector CT

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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