TY - GEN
T1 - Quantification of coronary calcification using high-resolution photon-counting-detector CT and an image domain denoising algorithm
AU - Vanmeter, Patrick D.
AU - Marsh, Jeffery
AU - Rajendran, Kishore
AU - Leng, Shuai
AU - McCollough, Cynthia
N1 - Funding Information:
Research reported in this work was supported by the National Institutes of Health under award number R01 EB028590 and C06 RR018898. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Health. This work was supported in part by the Mayo Clinic X-ray Imaging Research Core.
Publisher Copyright:
© 2022 SPIE.
PY - 2022
Y1 - 2022
N2 - Coronary artery calcification is an important indicator of coronary disease. Accurate volume quantification of coronary calcification using computed tomography (CT) is challenging due to calcium blooming. In this study, ex-vivo coronary specimens were scanned on an investigational photon-counting detector (PCD) CT scanner and the estimated coronary calcification volume were compared with a conventional energy-integrating detector (EID) CT. An image-based denoising algorithm was applied to the PCD-CT images to achieve similar noise levels as EID-CT. Calcifications were segmented to estimate the volume, with micro-CT images of the same calcifications serving as reference. PCD-CT images showed reduced calcium blooming artifacts.
AB - Coronary artery calcification is an important indicator of coronary disease. Accurate volume quantification of coronary calcification using computed tomography (CT) is challenging due to calcium blooming. In this study, ex-vivo coronary specimens were scanned on an investigational photon-counting detector (PCD) CT scanner and the estimated coronary calcification volume were compared with a conventional energy-integrating detector (EID) CT. An image-based denoising algorithm was applied to the PCD-CT images to achieve similar noise levels as EID-CT. Calcifications were segmented to estimate the volume, with micro-CT images of the same calcifications serving as reference. PCD-CT images showed reduced calcium blooming artifacts.
KW - Photon counting detector CT
KW - calcium quantification
KW - coronary artery disease
KW - coronary calcifications
KW - image domain denoising
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U2 - 10.1117/12.2612999
DO - 10.1117/12.2612999
M3 - Conference contribution
AN - SCOPUS:85131196485
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Medical Imaging 2022
A2 - Zhao, Wei
A2 - Yu, Lifeng
PB - SPIE
T2 - Medical Imaging 2022: Physics of Medical Imaging
Y2 - 21 March 2022 through 27 March 2022
ER -