Quality of life at diagnosis predicts overall survival in patients with aggressive lymphoma

Carrie A Thompson, Kathleen J Yost, Matthew J. Maurer, Cristine Allmer, Umar Farooq, Thomas Matthew Habermann, David J. Inwards, William R. Macon, Brian K. Link, Allison C. Rosenthal, James R Cerhan

Research output: Contribution to journalArticle

Abstract

Our aim was to evaluate whether quality of life (QOL) scores at diagnosis predict survival among patients with aggressive lymphoma. Newly diagnosed lymphoma patients were prospectively enrolled within 9 months of diagnosis in the University of Iowa/Mayo Clinic SPORE and systematically followed for event-free and overall survival (OS). QOL was measured with the Functional Assessment of Cancer Treatment-General (FACT-G), which measures 4 domains: physical, social/family, emotional, and functional well-being (WB); a single item Linear Analogue Self-Assessment (LASA) measuring overall QOL; and a spiritual WB LASA. From 9/2002 to 12/2009, 701 patients with aggressive lymphoma who completed baseline QOL questionnaires were enrolled. At a median follow-up of 71 months (range 6-128), 316 patients (45%) had an event and 228 patients (33%) died. All baseline QOL measures but emotional WB were significantly associated with OS (all P < 0.04); of which all but LASA spiritual remained significant after adjusting for IPI and NHL subtype. The strongest associations were with total FACT-G (adjusted HR = 0.86, 95% CI: 0.79-0.94, P = 0.00062) and functional WB (adjusted HR = 0.88, 95% CI: 0.83-0.93, P <.0001). QOL LASA was associated with OS (adjusted HR = 0.92, 95% CI: 0.87-0.97, P = 0.0041). Patients with clinically deficient QOL (overall QOL ≤50) had a median OS of 92 months compared with 121 months for patients with QOL >50 (P = 0.0004). In this large sample of patients with aggressive lymphoma, we found that baseline QOL is independently predictive of OS. QOL should be assessed as a prognostic factor in patients with aggressive lymphoma.

Original languageEnglish (US)
Pages (from-to)749-756
Number of pages8
JournalHematological Oncology
Volume36
Issue number5
DOIs
StatePublished - Dec 1 2018

Fingerprint

Lymphoma
Quality of Life
Survival
Disease-Free Survival
Neoplasms

Keywords

  • lymphoma
  • prognosis
  • quality of life
  • surveys and questionnaires
  • survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Quality of life at diagnosis predicts overall survival in patients with aggressive lymphoma. / Thompson, Carrie A; Yost, Kathleen J; Maurer, Matthew J.; Allmer, Cristine; Farooq, Umar; Habermann, Thomas Matthew; Inwards, David J.; Macon, William R.; Link, Brian K.; Rosenthal, Allison C.; Cerhan, James R.

In: Hematological Oncology, Vol. 36, No. 5, 01.12.2018, p. 749-756.

Research output: Contribution to journalArticle

Thompson, Carrie A ; Yost, Kathleen J ; Maurer, Matthew J. ; Allmer, Cristine ; Farooq, Umar ; Habermann, Thomas Matthew ; Inwards, David J. ; Macon, William R. ; Link, Brian K. ; Rosenthal, Allison C. ; Cerhan, James R. / Quality of life at diagnosis predicts overall survival in patients with aggressive lymphoma. In: Hematological Oncology. 2018 ; Vol. 36, No. 5. pp. 749-756.
@article{8b599bcd5e134a9f83f0de102170be24,
title = "Quality of life at diagnosis predicts overall survival in patients with aggressive lymphoma",
abstract = "Our aim was to evaluate whether quality of life (QOL) scores at diagnosis predict survival among patients with aggressive lymphoma. Newly diagnosed lymphoma patients were prospectively enrolled within 9 months of diagnosis in the University of Iowa/Mayo Clinic SPORE and systematically followed for event-free and overall survival (OS). QOL was measured with the Functional Assessment of Cancer Treatment-General (FACT-G), which measures 4 domains: physical, social/family, emotional, and functional well-being (WB); a single item Linear Analogue Self-Assessment (LASA) measuring overall QOL; and a spiritual WB LASA. From 9/2002 to 12/2009, 701 patients with aggressive lymphoma who completed baseline QOL questionnaires were enrolled. At a median follow-up of 71 months (range 6-128), 316 patients (45{\%}) had an event and 228 patients (33{\%}) died. All baseline QOL measures but emotional WB were significantly associated with OS (all P < 0.04); of which all but LASA spiritual remained significant after adjusting for IPI and NHL subtype. The strongest associations were with total FACT-G (adjusted HR = 0.86, 95{\%} CI: 0.79-0.94, P = 0.00062) and functional WB (adjusted HR = 0.88, 95{\%} CI: 0.83-0.93, P <.0001). QOL LASA was associated with OS (adjusted HR = 0.92, 95{\%} CI: 0.87-0.97, P = 0.0041). Patients with clinically deficient QOL (overall QOL ≤50) had a median OS of 92 months compared with 121 months for patients with QOL >50 (P = 0.0004). In this large sample of patients with aggressive lymphoma, we found that baseline QOL is independently predictive of OS. QOL should be assessed as a prognostic factor in patients with aggressive lymphoma.",
keywords = "lymphoma, prognosis, quality of life, surveys and questionnaires, survival",
author = "Thompson, {Carrie A} and Yost, {Kathleen J} and Maurer, {Matthew J.} and Cristine Allmer and Umar Farooq and Habermann, {Thomas Matthew} and Inwards, {David J.} and Macon, {William R.} and Link, {Brian K.} and Rosenthal, {Allison C.} and Cerhan, {James R}",
year = "2018",
month = "12",
day = "1",
doi = "10.1002/hon.2522",
language = "English (US)",
volume = "36",
pages = "749--756",
journal = "Hematological Oncology",
issn = "0278-0232",
publisher = "John Wiley and Sons Ltd",
number = "5",

}

TY - JOUR

T1 - Quality of life at diagnosis predicts overall survival in patients with aggressive lymphoma

AU - Thompson, Carrie A

AU - Yost, Kathleen J

AU - Maurer, Matthew J.

AU - Allmer, Cristine

AU - Farooq, Umar

AU - Habermann, Thomas Matthew

AU - Inwards, David J.

AU - Macon, William R.

AU - Link, Brian K.

AU - Rosenthal, Allison C.

AU - Cerhan, James R

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Our aim was to evaluate whether quality of life (QOL) scores at diagnosis predict survival among patients with aggressive lymphoma. Newly diagnosed lymphoma patients were prospectively enrolled within 9 months of diagnosis in the University of Iowa/Mayo Clinic SPORE and systematically followed for event-free and overall survival (OS). QOL was measured with the Functional Assessment of Cancer Treatment-General (FACT-G), which measures 4 domains: physical, social/family, emotional, and functional well-being (WB); a single item Linear Analogue Self-Assessment (LASA) measuring overall QOL; and a spiritual WB LASA. From 9/2002 to 12/2009, 701 patients with aggressive lymphoma who completed baseline QOL questionnaires were enrolled. At a median follow-up of 71 months (range 6-128), 316 patients (45%) had an event and 228 patients (33%) died. All baseline QOL measures but emotional WB were significantly associated with OS (all P < 0.04); of which all but LASA spiritual remained significant after adjusting for IPI and NHL subtype. The strongest associations were with total FACT-G (adjusted HR = 0.86, 95% CI: 0.79-0.94, P = 0.00062) and functional WB (adjusted HR = 0.88, 95% CI: 0.83-0.93, P <.0001). QOL LASA was associated with OS (adjusted HR = 0.92, 95% CI: 0.87-0.97, P = 0.0041). Patients with clinically deficient QOL (overall QOL ≤50) had a median OS of 92 months compared with 121 months for patients with QOL >50 (P = 0.0004). In this large sample of patients with aggressive lymphoma, we found that baseline QOL is independently predictive of OS. QOL should be assessed as a prognostic factor in patients with aggressive lymphoma.

AB - Our aim was to evaluate whether quality of life (QOL) scores at diagnosis predict survival among patients with aggressive lymphoma. Newly diagnosed lymphoma patients were prospectively enrolled within 9 months of diagnosis in the University of Iowa/Mayo Clinic SPORE and systematically followed for event-free and overall survival (OS). QOL was measured with the Functional Assessment of Cancer Treatment-General (FACT-G), which measures 4 domains: physical, social/family, emotional, and functional well-being (WB); a single item Linear Analogue Self-Assessment (LASA) measuring overall QOL; and a spiritual WB LASA. From 9/2002 to 12/2009, 701 patients with aggressive lymphoma who completed baseline QOL questionnaires were enrolled. At a median follow-up of 71 months (range 6-128), 316 patients (45%) had an event and 228 patients (33%) died. All baseline QOL measures but emotional WB were significantly associated with OS (all P < 0.04); of which all but LASA spiritual remained significant after adjusting for IPI and NHL subtype. The strongest associations were with total FACT-G (adjusted HR = 0.86, 95% CI: 0.79-0.94, P = 0.00062) and functional WB (adjusted HR = 0.88, 95% CI: 0.83-0.93, P <.0001). QOL LASA was associated with OS (adjusted HR = 0.92, 95% CI: 0.87-0.97, P = 0.0041). Patients with clinically deficient QOL (overall QOL ≤50) had a median OS of 92 months compared with 121 months for patients with QOL >50 (P = 0.0004). In this large sample of patients with aggressive lymphoma, we found that baseline QOL is independently predictive of OS. QOL should be assessed as a prognostic factor in patients with aggressive lymphoma.

KW - lymphoma

KW - prognosis

KW - quality of life

KW - surveys and questionnaires

KW - survival

UR - http://www.scopus.com/inward/record.url?scp=85058109098&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058109098&partnerID=8YFLogxK

U2 - 10.1002/hon.2522

DO - 10.1002/hon.2522

M3 - Article

VL - 36

SP - 749

EP - 756

JO - Hematological Oncology

JF - Hematological Oncology

SN - 0278-0232

IS - 5

ER -