Quality of life after videoscopic left cardiac sympathetic denervation in patients with potentially life-threatening cardiac channelopathies/cardiomyopathies

Ryan M. Antiel, J. Martijn Bos, Daniel D. Joyce, Heidi J. Owen, Penny L. Roskos, Christopher Moir, Michael J. Ackerman

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Background Left cardiac sympathetic denervation (LCSD) provides an additive or potentially alternative treatment option for patients with life-threatening cardiac channelopathies/cardiomyopathies. Objective We sought to examine the effects of LCSD on quality of life (QOL). Methods From November 2005 to May 2013, 109 patients who underwent LCSD were subsequently sent postoperative QOL surveys. Results Of 109 patients, 8 (7%) could not be contacted. Of the remaining 101 patients, 62 returned surveys (response rate 61%). There were an average of 4.1 ± 1.8 self-reported side effects immediately after LCSD. The most common anticipated side effects included unilateral hand dryness, color or temperature variance between sides of the face, and abnormal sweating. Although parent-reported pediatric physical QOL scores were lower than national norms, there were no differences in psychosocial QOL or disability scores (P =.09 and.33, respectively). QOL scores for adult patients were not significantly different from a US normative sample. Adult LCSD patients reported less disability than a US normative sample (P <.01). There was no correlation between QOL scores and the presence of anticipated side effects. However, among the subset of pediatric patients who continued to receive ventricular fibrillation-terminating implantable cardioverter-defibrillator shocks after LCSD, there was a correlation between their disability scores and the number of reported shocks (Spearman correlation = 0.56). The majority of patients/parents reported that they were very or somewhat satisfied with their surgery (or their child's surgery) and would definitely or probably recommend LCSD to another patient. Conclusion Despite the anticipated side effects associated with LCSD, patients are satisfied with their surgery and indicate that they would recommend the surgery to another patient.

Original languageEnglish (US)
Pages (from-to)62-69
Number of pages8
JournalHeart rhythm
Issue number1
StatePublished - Jan 1 2016


  • CPVT
  • Left cardiac sympathetic denervation
  • Long QT syndrome
  • Quality of life
  • Sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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