Quadrilateral space syndrome: the Mayo Clinic experience with a new classification system and case series

Sherry Ann N. Brown, Derrick A. Doolittle, Carol J. Bohanon, Arjun Jayaraj, Sailendra Naidu, Eric A. Huettl, Kevin J. Renfree, Gustavo Oderich, Haraldur Bjarnason, Peter Gloviczki, Waldemar E. Wysokinski, Ian R. McPhail

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Quadrilateral space syndrome (QSS) arises from compression or mechanical injury to the axillary nerve or the posterior circumflex humeral artery (PCHA) as they pass through the quadrilateral space (QS). Quadrilateral space syndrome is an uncommon cause of paresthesia and an underdiagnosed cause of digital ischemia in overhead athletes. Quadrilateral space syndrome can present with neurogenic symptoms (pain and weakness) secondary to axillary nerve compression. In addition, repeated abduction and external rotation of the arm is felt to lead to injury of the PCHA within the QSS. This often results in PCHA thrombosis and aneurysm formation, with distal emboli. Because of relative infrequency, QSS is rarely diagnosed on evaluation of athletes with such symptoms. We report on 9 patients who presented at Mayo Clinic with QSS. Differential diagnosis, a new classification system, and the management of QSS are discussed, with a comprehensive literature review. The following search terms were used on PubMed: axillary nerve, posterior circumflex humeral artery, quadrilateral space, and quadrangular space. Articles were selected if they described patients with symptoms from axillary nerve entrapment or PCHA thrombosis, or if related screening or imaging methods were assessed. References available within the obtained articles were also pursued. There was no date or language restriction for article inclusion; 5 studies in languages besides English were reported in German, French, Spanish, Turkish, and Chinese.

Original languageEnglish (US)
Pages (from-to)382-394
Number of pages13
JournalMayo Clinic Proceedings
Volume90
Issue number3
DOIs
StatePublished - Mar 1 2015

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Arteries
Athletes
Thrombosis
Language
Nerve Compression Syndromes
Paresthesia
Wounds and Injuries
Embolism
PubMed
Aneurysm
Differential Diagnosis
Ischemia
Pain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Brown, S. A. N., Doolittle, D. A., Bohanon, C. J., Jayaraj, A., Naidu, S., Huettl, E. A., ... McPhail, I. R. (2015). Quadrilateral space syndrome: the Mayo Clinic experience with a new classification system and case series. Mayo Clinic Proceedings, 90(3), 382-394. https://doi.org/10.1016/j.mayocp.2014.12.012

Quadrilateral space syndrome : the Mayo Clinic experience with a new classification system and case series. / Brown, Sherry Ann N.; Doolittle, Derrick A.; Bohanon, Carol J.; Jayaraj, Arjun; Naidu, Sailendra; Huettl, Eric A.; Renfree, Kevin J.; Oderich, Gustavo; Bjarnason, Haraldur; Gloviczki, Peter; Wysokinski, Waldemar E.; McPhail, Ian R.

In: Mayo Clinic Proceedings, Vol. 90, No. 3, 01.03.2015, p. 382-394.

Research output: Contribution to journalReview article

Brown, SAN, Doolittle, DA, Bohanon, CJ, Jayaraj, A, Naidu, S, Huettl, EA, Renfree, KJ, Oderich, G, Bjarnason, H, Gloviczki, P, Wysokinski, WE & McPhail, IR 2015, 'Quadrilateral space syndrome: the Mayo Clinic experience with a new classification system and case series', Mayo Clinic Proceedings, vol. 90, no. 3, pp. 382-394. https://doi.org/10.1016/j.mayocp.2014.12.012
Brown, Sherry Ann N. ; Doolittle, Derrick A. ; Bohanon, Carol J. ; Jayaraj, Arjun ; Naidu, Sailendra ; Huettl, Eric A. ; Renfree, Kevin J. ; Oderich, Gustavo ; Bjarnason, Haraldur ; Gloviczki, Peter ; Wysokinski, Waldemar E. ; McPhail, Ian R. / Quadrilateral space syndrome : the Mayo Clinic experience with a new classification system and case series. In: Mayo Clinic Proceedings. 2015 ; Vol. 90, No. 3. pp. 382-394.
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