Pyridoxine neuropathy in rats: Specific degeneration of sensory axons

Anthony J. Windebank, Phillip A. Low, Marceil D. Blexrud, James D. Schmelzer, Herbert H. Schaumburg

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52 Scopus citations

Abstract

When rats received pyridoxine in doses large enough to cause neuropathy in humans, the animals developed gait ataxia that subsided alter the toxin was withdrawn. By using quantitative histologic techniques, we found axonal degeneration of sensory system fibers and that the fibers derived from the ventral root were spared. Although the degeneration approached the dorsal root ganglion, neurons in the ganglion did not degenerate. We found no early decrease in oxygen consumption of nerve, suggesting that impaired oxidative metabolism was not the primary event.

Original languageEnglish (US)
Pages (from-to)1617-1622
Number of pages6
JournalNeurology
Volume35
Issue number11
StatePublished - Nov 1985

ASJC Scopus subject areas

  • Clinical Neurology

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    Windebank, A. J., Low, P. A., Blexrud, M. D., Schmelzer, J. D., & Schaumburg, H. H. (1985). Pyridoxine neuropathy in rats: Specific degeneration of sensory axons. Neurology, 35(11), 1617-1622.