Putative GH pulse renewal: Periventricular somatostatinergic control of an arcuate-nuclear somatostatin and GH-releasing hormone oscillator

Leon S. Farhy, Johannes D Veldhuis

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Growth hormone (GH) pulsatility requires periventricular-nuclear somatostatin (SRIFPeV), arcuate-nuclear (ArC) GH-releasing hormone (GHRH), and systemic GH autofeedback. However, no current formalism interlinks these regulatory loci in a manner that generates self-renewable GH dynamics, The latter must include in the adult rat 1) infrequent volleys of high-amplitude GH peaks in the male, 2) frequent discrete low-amplitude GH pulses in the female, 3) disruption of the male pattern by severing SRIF PeV outflow to ArC, 4) stimulation of GHRH and GH secretion by central nervous system delivery of SRIF, 5) inhibition of GH release by central exposure to GHRH, and 6) a reboundlike burst of GHRH secretion induced by stopping peripheral infusion of SRIF. The present study validates by computer-assisted simulations a simplified ensemble formulation that predicts each of the foregoing six outcomes, wherein 1) blood-borne GH stimulates SRIFPeV secretion after a long time latency, 2) SRIFPeV inhibits both pituitary GH and ArC GHRH release, 3) ArC GHRH and SRIF ArC oscillate reciprocally with brief time delay, and 4) SRIF PeV represses and disinhibits the putative GHRH-SRIFArC oscillator. According to the present analytic construction, time-delayed feedforward and feedback signaling among SRIFPeV, ArC GHRH, and SRIFArC could endow the complex physiological patterns of GH secretion in the male and female.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume286
Issue number6 55-6
DOIs
StatePublished - Jun 2004

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Growth Hormone-Releasing Hormone
Somatostatin
Growth Hormone
Hormones
Computer Simulation
Central Nervous System

Keywords

  • Autofeedback
  • Feedback
  • Growth hormone
  • Hormone pulsatility
  • Hypothalamus
  • Mathematical model
  • Pituitary
  • Somatotropic axis

ASJC Scopus subject areas

  • Physiology

Cite this

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title = "Putative GH pulse renewal: Periventricular somatostatinergic control of an arcuate-nuclear somatostatin and GH-releasing hormone oscillator",
abstract = "Growth hormone (GH) pulsatility requires periventricular-nuclear somatostatin (SRIFPeV), arcuate-nuclear (ArC) GH-releasing hormone (GHRH), and systemic GH autofeedback. However, no current formalism interlinks these regulatory loci in a manner that generates self-renewable GH dynamics, The latter must include in the adult rat 1) infrequent volleys of high-amplitude GH peaks in the male, 2) frequent discrete low-amplitude GH pulses in the female, 3) disruption of the male pattern by severing SRIF PeV outflow to ArC, 4) stimulation of GHRH and GH secretion by central nervous system delivery of SRIF, 5) inhibition of GH release by central exposure to GHRH, and 6) a reboundlike burst of GHRH secretion induced by stopping peripheral infusion of SRIF. The present study validates by computer-assisted simulations a simplified ensemble formulation that predicts each of the foregoing six outcomes, wherein 1) blood-borne GH stimulates SRIFPeV secretion after a long time latency, 2) SRIFPeV inhibits both pituitary GH and ArC GHRH release, 3) ArC GHRH and SRIF ArC oscillate reciprocally with brief time delay, and 4) SRIF PeV represses and disinhibits the putative GHRH-SRIFArC oscillator. According to the present analytic construction, time-delayed feedforward and feedback signaling among SRIFPeV, ArC GHRH, and SRIFArC could endow the complex physiological patterns of GH secretion in the male and female.",
keywords = "Autofeedback, Feedback, Growth hormone, Hormone pulsatility, Hypothalamus, Mathematical model, Pituitary, Somatotropic axis",
author = "Farhy, {Leon S.} and Veldhuis, {Johannes D}",
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T2 - Periventricular somatostatinergic control of an arcuate-nuclear somatostatin and GH-releasing hormone oscillator

AU - Farhy, Leon S.

AU - Veldhuis, Johannes D

PY - 2004/6

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N2 - Growth hormone (GH) pulsatility requires periventricular-nuclear somatostatin (SRIFPeV), arcuate-nuclear (ArC) GH-releasing hormone (GHRH), and systemic GH autofeedback. However, no current formalism interlinks these regulatory loci in a manner that generates self-renewable GH dynamics, The latter must include in the adult rat 1) infrequent volleys of high-amplitude GH peaks in the male, 2) frequent discrete low-amplitude GH pulses in the female, 3) disruption of the male pattern by severing SRIF PeV outflow to ArC, 4) stimulation of GHRH and GH secretion by central nervous system delivery of SRIF, 5) inhibition of GH release by central exposure to GHRH, and 6) a reboundlike burst of GHRH secretion induced by stopping peripheral infusion of SRIF. The present study validates by computer-assisted simulations a simplified ensemble formulation that predicts each of the foregoing six outcomes, wherein 1) blood-borne GH stimulates SRIFPeV secretion after a long time latency, 2) SRIFPeV inhibits both pituitary GH and ArC GHRH release, 3) ArC GHRH and SRIF ArC oscillate reciprocally with brief time delay, and 4) SRIF PeV represses and disinhibits the putative GHRH-SRIFArC oscillator. According to the present analytic construction, time-delayed feedforward and feedback signaling among SRIFPeV, ArC GHRH, and SRIFArC could endow the complex physiological patterns of GH secretion in the male and female.

AB - Growth hormone (GH) pulsatility requires periventricular-nuclear somatostatin (SRIFPeV), arcuate-nuclear (ArC) GH-releasing hormone (GHRH), and systemic GH autofeedback. However, no current formalism interlinks these regulatory loci in a manner that generates self-renewable GH dynamics, The latter must include in the adult rat 1) infrequent volleys of high-amplitude GH peaks in the male, 2) frequent discrete low-amplitude GH pulses in the female, 3) disruption of the male pattern by severing SRIF PeV outflow to ArC, 4) stimulation of GHRH and GH secretion by central nervous system delivery of SRIF, 5) inhibition of GH release by central exposure to GHRH, and 6) a reboundlike burst of GHRH secretion induced by stopping peripheral infusion of SRIF. The present study validates by computer-assisted simulations a simplified ensemble formulation that predicts each of the foregoing six outcomes, wherein 1) blood-borne GH stimulates SRIFPeV secretion after a long time latency, 2) SRIFPeV inhibits both pituitary GH and ArC GHRH release, 3) ArC GHRH and SRIF ArC oscillate reciprocally with brief time delay, and 4) SRIF PeV represses and disinhibits the putative GHRH-SRIFArC oscillator. According to the present analytic construction, time-delayed feedforward and feedback signaling among SRIFPeV, ArC GHRH, and SRIFArC could endow the complex physiological patterns of GH secretion in the male and female.

KW - Autofeedback

KW - Feedback

KW - Growth hormone

KW - Hormone pulsatility

KW - Hypothalamus

KW - Mathematical model

KW - Pituitary

KW - Somatotropic axis

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