Pulsed electric fields for cardiac ablation and beyond: A state-of-the-art review

Elad Maor, Alan Sugrue, Chance Witt, Vaibhav R. Vaidya, Christopher V. DeSimone, Samuel J Asirvatham, Suraj Kapa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Irreversible electroporation (IRE) occurs when a strong, pulsed electric field (PEF) causes permeabilization of the cell membrane, leading to cellular homeostasis disruption and cell death. IRE is a Food and Drug Administration–approved treatment of tumor ablation and has been gaining attention in cardiology as an ablation modality. Applications of PEF in cardiology are vast and include atrial fibrillation, ventricular fibrillation, septal ablation, and targeting vascular structures. PEF has appealing characteristics, including the ability to be tissue specific and its nonthermal nature. This review provides information on the biophysics and mechanisms of IRE, summarizes key studies and applications to date, and provides insight into future applications.

Original languageEnglish (US)
Pages (from-to)1112-1120
Number of pages9
JournalHeart rhythm
Volume16
Issue number7
DOIs
StatePublished - Jul 1 2019

Fingerprint

Electroporation
Cardiology
Biophysics
Ventricular Fibrillation
Atrial Fibrillation
Blood Vessels
Homeostasis
Cell Death
Cell Membrane
Food
Pharmaceutical Preparations
Neoplasms

Keywords

  • Ablation
  • Electroporation
  • Irreversible electroporation
  • Pulsed electric fields
  • Radiofrequency

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Pulsed electric fields for cardiac ablation and beyond : A state-of-the-art review. / Maor, Elad; Sugrue, Alan; Witt, Chance; Vaidya, Vaibhav R.; DeSimone, Christopher V.; Asirvatham, Samuel J; Kapa, Suraj.

In: Heart rhythm, Vol. 16, No. 7, 01.07.2019, p. 1112-1120.

Research output: Contribution to journalArticle

Maor, Elad ; Sugrue, Alan ; Witt, Chance ; Vaidya, Vaibhav R. ; DeSimone, Christopher V. ; Asirvatham, Samuel J ; Kapa, Suraj. / Pulsed electric fields for cardiac ablation and beyond : A state-of-the-art review. In: Heart rhythm. 2019 ; Vol. 16, No. 7. pp. 1112-1120.
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