Pulse width is associated with cognitive decline after thalamic stimulation for essential tremor

Steven Paul Woods, Julie A Fields, Kelly E. Lyons, Rajesh Pahwa, Alexander I. Tröster

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The present study sought to identify predictors of cognitive decline after thalamic deep brain stimulation (DBS) for essential tremor (ET). Twenty-seven patients (55%) with ET demonstrated mild cognitive decrements relative to pre-surgical baseline (ET-D), whereas 22 patients (45%) were classified as neuropsychologically stable (ET-S). The ET-D and ET-S groups were comparable in terms of baseline demographic, disease, and neuropsychological characteristics, as well as post-surgical motor outcomes. However, the ET-D group had significantly higher pulse width (PW) stimulator settings, and a greater proportion of ET-D than ET-S patients underwent left in comparison to right thalamic stimulation. A subsequent step-wise discriminant function analysis revealed that disease onset after age 37 years and higher PW settings (≥120 μs) were the strongest predictors of post-surgical cognitive decline in this sample. Findings indicate that although relatively higher PW settings might afford optimal tremor control in some patients, the corresponding risk of mild, probably often subclinical, cognitive morbidity must be weighed accordingly.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalParkinsonism and Related Disorders
Volume9
Issue number5
DOIs
StatePublished - Jun 2003
Externally publishedYes

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Keywords

  • Deep brain stimulation
  • Essential tremor
  • Neuropsychology
  • Thalamus

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Neurology

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