Pulse Transmission Coefficient: A Nonhyperemic Index for Physiologic Assessment of Procedural Success Following Percutaneous Coronary Interventions

David Brosh, Stuart T. Higano, Morton J. Kern, Ryan J. Lennon, David Holmes, Amir Lerman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Intracoronary pressure measurements and the determination of fractional flow reserve (FFR) after percutaneous coronary intervention (PCI) predict adverse events. Coronary lesions may impair the transmission of pressure waves across a stenosis, potentially acting as a high-frequency filter. The pulse transmission coefficient (PTC) is a nonhyperemic parameter that calculates the transmission of high-frequency components of the pressure signal through a stenosis. It was shown recently that PTC is highly correlated with FFR. This study was designed to examine the change of PTC as compared to FFR following PCI. Pressure signals were obtained by pressure guidewire in 27 lesions pre- and post-PCI and were analyzed with an algorithm that identifies the high-frequency component in the pressure signal. The PTC was calculated at baseline as the ratio between distal and proximal high-frequency components of the pressure waveform across the lesion. FFR measurements were assessed with intracoronary adenosine. There was a significant increase in PTC following PCI (0.15 ± 0.17 at baseline vs. 0.84 ± 0.11 post-PCI; P < 0.001). Comparable changes were observed for FFR (0.58 ± 0.12 at baseline vs. 0.91 ± 0.05 post-PCI; P < 0.001). PTC is a nonhyperemic parameter for physiologic assessment of coronary artery stenoses. Similar to FFR, PTC is significantly increased following PCI. Thus, it may serve as an adjunct index for the functional assessment of procedural success following PCI.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalCatheterization and Cardiovascular Interventions
Volume61
Issue number1
DOIs
StatePublished - Jan 2004

Fingerprint

Percutaneous Coronary Intervention
Pressure
Pathologic Constriction
Coronary Stenosis
Adenosine

Keywords

  • Adenosine
  • Coefficient
  • Coronary artery disease
  • Fractional flow reserve
  • Percutaneous coronary intervention
  • Pulse transmission

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Pulse Transmission Coefficient : A Nonhyperemic Index for Physiologic Assessment of Procedural Success Following Percutaneous Coronary Interventions. / Brosh, David; Higano, Stuart T.; Kern, Morton J.; Lennon, Ryan J.; Holmes, David; Lerman, Amir.

In: Catheterization and Cardiovascular Interventions, Vol. 61, No. 1, 01.2004, p. 95-102.

Research output: Contribution to journalArticle

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