Pulmonary veno-occlusive disease

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Imaging description Pulmonary veno-occlusive disease (PVOD) is considered a cause of pulmonary hypertension that preferentially affects the post-capillary pulmonary vasculature. The pathologic hallmark of PVOD is the extensive and diffuse occlusion of pulmonary veins by fibrous tissue. The imaging findings are a result of this fibrotic occlusion. Pulmonary and pleural lymphatics are dilated. The most consistent parenchymal change is thickening of the interlobular septa due to interstitial edema and deposition of collagen fibers along the septa [1]. On CT chest this is seen as peripheral interlobular septal thickening (Figures 57.1 and 57.2) Alveolar capillaries may become engorged and tortuous, and may resemble pulmonary capillary hemangiomatosis. On CT this is manifested by ground-glass opacities, predominately centrilobular ground-glass nodular opacities [2] (Figures 57.2 and 57.3). Other associated findings at CT include pleural effusions, pericardial effusions, enlarged central pulmonary arteries, normal central pulmonary vein and left atrium size, and mediastinal adenopathy. Importance The clinical presentation of PVOD (dyspnea, fatigue) is similar to primary pulmonary hypertension (PPH), but the treatments for PPH (vasodilator therapies) can be harmful and occasionally fatal in patients with PVOD, as they can induce fulminant pulmonary edema [2].

Original languageEnglish (US)
Title of host publicationPearls and Pitfalls in Thoracic Imaging
Subtitle of host publicationVariants and Other Difficult Diagnoses
PublisherCambridge University Press
Pages150-153
Number of pages4
Volume9780521119078
ISBN (Electronic)9780511977701
ISBN (Print)9780521119078
DOIs
StatePublished - Jan 1 2011

ASJC Scopus subject areas

  • Medicine(all)

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    Sykes, A. M. (2011). Pulmonary veno-occlusive disease. In Pearls and Pitfalls in Thoracic Imaging: Variants and Other Difficult Diagnoses (Vol. 9780521119078, pp. 150-153). Cambridge University Press. https://doi.org/10.1017/CBO9780511977701.058