Pulmonary T cells and eosinophils: Coconspirators or independent triggers of allergic respiratory pathology?

Nancy A Lee, Erwin W. Gelfand, James J. Lee

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Etiologic discussions of allergic respiratory pathology frequently engender rabid constituencies of pro-T cell or proeosinophil disciples, each claiming, often with religious fervor, the importance of their leukocyte. However, increasing evidence suggests that the exclusionary rhetoric from either camp is inadequate to explain many of the pathologic changes occurring in the lung. Data from both asthmatic patient and mouse models of allergic respiratory inflammation suggest that, in addition to cell-autonomous activities, T-cell and eosinophil interactions may be critical to the onset and progression of pulmonary pathology. These studies also suggest that T-lymphocyte subpopulations and eosinophils communicate by means of both direct cell-cell interactions and through the secretion of inflammatory signals. Collectively, the data support an expanded view of T-cell and eosinophil activities in the lung, including both immunoregulative activities and downstream effector functions impinging directly on lung function.

Original languageEnglish (US)
Pages (from-to)945-957
Number of pages13
JournalJournal of Allergy and Clinical Immunology
Volume107
Issue number6
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Eosinophils
Pathology
T-Lymphocytes
Lung
Cell Communication
Lymphocyte Subsets
Leukocytes
Inflammation

Keywords

  • Eosinophil asthma
  • Gene knockout
  • Mouse models
  • T cell
  • T 2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Pulmonary T cells and eosinophils : Coconspirators or independent triggers of allergic respiratory pathology? / Lee, Nancy A; Gelfand, Erwin W.; Lee, James J.

In: Journal of Allergy and Clinical Immunology, Vol. 107, No. 6, 2001, p. 945-957.

Research output: Contribution to journalArticle

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