TY - JOUR
T1 - Pulmonary Mycobacterial Spindle Cell Pseudotumor
T2 - A Report of 3 Cases Including a Practical Approach to Histopathologic Recognition of This Unusual Entity
AU - Boylan, Katherine E.
AU - Larsen, Brandon T.
AU - Young, Brittany A.
AU - Downs-Kelly, Erinn
AU - Panchabhai, Tanmay S.
AU - Collum, Earle S.
AU - Jensen, Leif
AU - Emerson, Lyska L.
N1 - Publisher Copyright:
© The Author(s) 2018.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Mycobacterial spindle cell pseudotumor (MSP) is a rare benign spindle cell lesion containing acid-fact mycobacteria. These lesions are most commonly identified in the lymph nodes, skin, spleen, or bone marrow of immunocompromised patients and only rarely involve the lungs. We report 3 cases of pulmonary MSP, which include 2 patients who are known to be HIV-positive. The histopathological diagnosis of MSP in the lung lends itself to many challenges due to its rare incidence and its spindled tumor-like appearance. The differential diagnosis is broad and includes both benign and malignant entities. We highlight the importance of the clinical context in which these lesions typically present and the morphologic spectrum of features seen, and we offer a practical approach to the workup of pulmonary mycobacterial pseudotumor. Appropriate recognition of this entity should lead to an accurate diagnosis of a treatable benign condition despite the clinical presentation often favoring malignancy.
AB - Mycobacterial spindle cell pseudotumor (MSP) is a rare benign spindle cell lesion containing acid-fact mycobacteria. These lesions are most commonly identified in the lymph nodes, skin, spleen, or bone marrow of immunocompromised patients and only rarely involve the lungs. We report 3 cases of pulmonary MSP, which include 2 patients who are known to be HIV-positive. The histopathological diagnosis of MSP in the lung lends itself to many challenges due to its rare incidence and its spindled tumor-like appearance. The differential diagnosis is broad and includes both benign and malignant entities. We highlight the importance of the clinical context in which these lesions typically present and the morphologic spectrum of features seen, and we offer a practical approach to the workup of pulmonary mycobacterial pseudotumor. Appropriate recognition of this entity should lead to an accurate diagnosis of a treatable benign condition despite the clinical presentation often favoring malignancy.
KW - Mycobacterium avium-intracellulare
KW - atypical mycobacteria
KW - histoid
KW - immunosuppression
KW - pseudotumor
KW - pulmonary nontuberculous mycobacteria
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U2 - 10.1177/1066896918770010
DO - 10.1177/1066896918770010
M3 - Article
C2 - 29720005
AN - SCOPUS:85053638785
SN - 1066-8969
VL - 26
SP - 629
EP - 634
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
IS - 7
ER -