TY - JOUR
T1 - Pulmonary Lymphangiomyomatosis
T2 - With Particular Reference to Steroid-Receptor Assay Studies and Pathologic Correlation
AU - GRAHAM, MARK L.
AU - SPELSBERG, THOMAS C.
AU - DINES, DAVID E.
AU - SPENCER PAYNE, W.
AU - BJORNSSON, JOHANNES
AU - LIE, J. T.
PY - 1984
Y1 - 1984
N2 - The symptoms of progressive dyspnea, hemoptysis, spontaneous pneumothorax, chylous effusions, and cough in conjunction with ventilatory obstruction and abnormal gas exchange in a young woman should prompt the diagnosis of pulmonary lymphangiomyomatosis. Cytosol steroid-receptor assays and postmortem studies were conducted in an extensive investigation of a case of this disease. A biopsy specimen of the lung disclosed evidence of nuclear translocation of [3H]progesterone and the presence of a cytosolic receptor for progesterone, an indication that this disease could be treated effectively with progestin.
AB - The symptoms of progressive dyspnea, hemoptysis, spontaneous pneumothorax, chylous effusions, and cough in conjunction with ventilatory obstruction and abnormal gas exchange in a young woman should prompt the diagnosis of pulmonary lymphangiomyomatosis. Cytosol steroid-receptor assays and postmortem studies were conducted in an extensive investigation of a case of this disease. A biopsy specimen of the lung disclosed evidence of nuclear translocation of [3H]progesterone and the presence of a cytosolic receptor for progesterone, an indication that this disease could be treated effectively with progestin.
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U2 - 10.1016/S0025-6196(12)60333-4
DO - 10.1016/S0025-6196(12)60333-4
M3 - Article
C2 - 6694430
AN - SCOPUS:0021357775
SN - 0025-6196
VL - 59
SP - 3
EP - 11
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
IS - 1
ER -