Pulmonary Lymphangiomyomatosis: With Particular Reference to Steroid-Receptor Assay Studies and Pathologic Correlation

MARK L. GRAHAM, THOMAS C. SPELSBERG, DAVID E. DINES, W. SPENCER PAYNE, JOHANNES BJORNSSON, J. T. LIE

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39 Scopus citations

Abstract

The symptoms of progressive dyspnea, hemoptysis, spontaneous pneumothorax, chylous effusions, and cough in conjunction with ventilatory obstruction and abnormal gas exchange in a young woman should prompt the diagnosis of pulmonary lymphangiomyomatosis. Cytosol steroid-receptor assays and postmortem studies were conducted in an extensive investigation of a case of this disease. A biopsy specimen of the lung disclosed evidence of nuclear translocation of [3H]progesterone and the presence of a cytosolic receptor for progesterone, an indication that this disease could be treated effectively with progestin.

Original languageEnglish (US)
Pages (from-to)3-11
Number of pages9
JournalMayo Clinic proceedings
Volume59
Issue number1
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Medicine(all)

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    GRAHAM, MARK. L., SPELSBERG, THOMAS. C., DINES, DAVID. E., SPENCER PAYNE, W., BJORNSSON, JOHANNES., & LIE, J. T. (1984). Pulmonary Lymphangiomyomatosis: With Particular Reference to Steroid-Receptor Assay Studies and Pathologic Correlation. Mayo Clinic proceedings, 59(1), 3-11. https://doi.org/10.1016/S0025-6196(12)60333-4