Pulmonary infiltrates following administration of paclitaxel

Ramesh K. Ramanathan, Vundyala V. Reddy, J. Michael Holbert, Chandra P. Belani

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

The clinical spectrum of hypersensitivity reactions reported with paclitaxel has not included the occurrence of pulmonary infiltrates. This report describes three patients who developed transient pulmonary infiltrates after receiving paclitaxel. These infiltrates were noted 2 days to 2 weeks after administration of paclitaxel. The infiltrates resolved spontaneously in all the patients but one of them did receive steroid therapy. This syndrome of transient pulmonary infiltrates did not reoccur in the two patients who were rechallenged with paclitaxel. Physicians should be made aware of this unique occurrence during the course of treatment with paclitaxel.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalChest
Volume110
Issue number1
DOIs
StatePublished - Jan 1 1996

Keywords

  • carboplatin
  • hypersensitivity reaction
  • nonsmall cell lung cancer
  • paclitaxel
  • pulmonary infiltrates

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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