Pulmonary embolism in ischemic stroke

clinical presentation, risk factors, and outcome.

Jitphapa Pongmoragot, Alejandro Rabinstein, Yongchai Nilanont, Richard H. Swartz, Limei Zhou, Gustavo Saposnik

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Limited information is available on the frequency of pulmonary embolism (PE) in patients with an acute ischemic stroke (AIS). We evaluated clinical characteristics, predisposing factors, and outcomes in AIS patients with PE. We included all AIS patients admitted to participating institutions in the Registry of the Canadian Stroke Network. Clinically PE was documented by a physician and confirmed by computed tomography pulmonary angiography within 30 days of the stroke case index. The primary outcome was death or disability at discharge. Secondary outcomes included disposition, length of hospital stay, mortality at 3 months and 1 year. Among 11 287 patients with AIS, PE was found in 89 (0.78%) patients. History of cancer, deep vein thrombosis (DVT)/PE, and DVT during the hospitalization were associated with PE. PE was associated with higher risk of death at 30 days (25.8% versus 13.6%; P<0.001), at 1 year (47.2% versus 24.6%; P<0.001), and disability at discharge (85.4% versus 63.6%; P<0.001). Mean length of stay was longer in stroke patients with PE (36 versus 16 days; P=0.001). After adjusting for age, sex, and stroke severity, PE remained associated with lower survival at 30 days and 1 year, and death or disability at discharge (OR 3.02; 95% CI 1.56 to 5.83). In this large cohort study, PE occurred in nearly 1% of AIS patients. PE was more common in patients with severe stroke, history of cancer, previous DVT/PE or acute DVT and associated with lower short- and long-term survival, greater disability, and longer length of stay.

Original languageEnglish (US)
JournalJournal of the American Heart Association
Volume2
Issue number6
DOIs
StatePublished - Jan 1 2013

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Pulmonary Embolism
Stroke
Venous Thrombosis
Length of Stay
Survival
Hospital Mortality
Causality
Registries
Neoplasms
Hospitalization
Cohort Studies
Physicians
Lung

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pulmonary embolism in ischemic stroke : clinical presentation, risk factors, and outcome. / Pongmoragot, Jitphapa; Rabinstein, Alejandro; Nilanont, Yongchai; Swartz, Richard H.; Zhou, Limei; Saposnik, Gustavo.

In: Journal of the American Heart Association, Vol. 2, No. 6, 01.01.2013.

Research output: Contribution to journalArticle

Pongmoragot, Jitphapa ; Rabinstein, Alejandro ; Nilanont, Yongchai ; Swartz, Richard H. ; Zhou, Limei ; Saposnik, Gustavo. / Pulmonary embolism in ischemic stroke : clinical presentation, risk factors, and outcome. In: Journal of the American Heart Association. 2013 ; Vol. 2, No. 6.
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