Pulmonary embolism: Diagnosis with contrast-enhanced electron-beam CT and comparison with pulmonary angiography

Corey L. Teigen, Timothy P. Maus, Patrick F. Sheedy, Anthony W. Stanson, C. Michael Johnson, Jerome F. Breen, Michael A. McKusick

Research output: Contribution to journalArticle

218 Scopus citations

Abstract

PURPOSE: To determine the sensitivity and specificity of contrast material-enhanced electron-beam computed tomography (CT) in the diagnosis of pulmonary embolism (PE). MATERIALS AND METHODS: Sixty patients suspected of having PE were prospectively evaluated with pulmonary angiography and contrast-enhanced electron-beam CT. Thirty-eight patients underwent ventilation-perfusion (V-P [also known as V/Q]) scanning. The pulmonary vasculature was divided into 12 anatomic zones. CT and angiographic findings were correlated on a patient-by-patient basis and for each vascular zone. RESULTS: Both studies were negative for PE in 36 patients. Both studies were positive in 15 patients, with the site of the emboli correlating well. Prospective sensitivity of CT was 65%; specificity, 97%; positive predictive value, 94%; and negative predictive value, 82%. After review of the nine discordant cases, sensitivity and specificity approached 100% for clinically important acute PE. CT depicted central and peripheral emboli equally well. CT was more sensitive and specific than V-P scanning. CONCLUSION: Electron- beam CT is a sensitive and specific noninvasive method for the diagnosis of PE. It has the potential to replace V-P scanning as the primary screening examination for PE.

Original languageEnglish (US)
Pages (from-to)313-319
Number of pages7
JournalRadiology
Volume194
Issue number2
DOIs
StatePublished - Feb 1995

Keywords

  • Embolism, pulmonary
  • Pulmonary angiography
  • Pulmonary arteries, CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Teigen, C. L., Maus, T. P., Sheedy, P. F., Stanson, A. W., Johnson, C. M., Breen, J. F., & McKusick, M. A. (1995). Pulmonary embolism: Diagnosis with contrast-enhanced electron-beam CT and comparison with pulmonary angiography. Radiology, 194(2), 313-319. https://doi.org/10.1148/radiology.194.2.7824704