Pulmonary embolism attenuation is a potential imaging biomarker for pulmonary artery hemodynamic improvement after catheter-directed thrombolysis

Edwin A. Takahashi, Christopher J. Reisenauer, Andrew H. Stockland, Haraldur Bjarnason, Melissa J. Neisen, Newton B. Neidert, William S. Harmsen, Courtney N. Day, Sanjay Misra

Research output: Contribution to journalArticle

Abstract

This study examined the potential correlation between pulmonary embolism (PE) attenuation on computed tomography pulmonary angiography (CTPA) and pulmonary artery hemodynamic response to catheter-directed thrombolysis (CDT) in 10 patients with submassive PE. Treatment parameters, PE attenuation, clot burden, computed tomography signs of right ventricle dysfunction and right ventricular systolic pressure at echocardiography were retrospectively analyzed to determine correlation with pulmonary artery pressure improvement using Spearman correlation. A single reader, blinded to the treatment results, measured PE attenuation of all patients. There was a significant positive correlation between PE attenuation and absolute pulmonary artery pressure improvement with a Spearman correlation of 0.741, p=0.014. When attenuation was greater than or equal to the median (44.5 HU, n=5), CDT was associated with significantly better pulmonary artery pressure improvement (p=0.037). Clot attenuation at CTPA may be a potential imaging biomarker for predicting pulmonary artery pressure improvement after CDT.

Original languageEnglish (US)
Pages (from-to)134-138
Number of pages5
JournalVascular Medicine (United Kingdom)
Volume23
Issue number2
DOIs
StatePublished - Apr 1 2018

Keywords

  • computed tomographic angiography (CTA)
  • pulmonary embolism (PE)
  • thrombolytic therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Takahashi, E. A., Reisenauer, C. J., Stockland, A. H., Bjarnason, H., Neisen, M. J., Neidert, N. B., Harmsen, W. S., Day, C. N., & Misra, S. (2018). Pulmonary embolism attenuation is a potential imaging biomarker for pulmonary artery hemodynamic improvement after catheter-directed thrombolysis. Vascular Medicine (United Kingdom), 23(2), 134-138. https://doi.org/10.1177/1358863X18756504