TY - JOUR
T1 - Pulmonary embolism attenuation is a potential imaging biomarker for pulmonary artery hemodynamic improvement after catheter-directed thrombolysis
AU - Takahashi, Edwin A.
AU - Reisenauer, Christopher J.
AU - Stockland, Andrew H.
AU - Bjarnason, Haraldur
AU - Neisen, Melissa J.
AU - Neidert, Newton B.
AU - Harmsen, William S.
AU - Day, Courtney N.
AU - Misra, Sanjay
N1 - Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Dr Misra has R01 NIH funding (HL098967 and DK107870). This work was supported by National Institutes of Health grant HL098967 from the National Heart, Lung, and Blood Institute and DK107870, from the National Institue of Diabetes and Digestive and Kidney Diseases.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - This study examined the potential correlation between pulmonary embolism (PE) attenuation on computed tomography pulmonary angiography (CTPA) and pulmonary artery hemodynamic response to catheter-directed thrombolysis (CDT) in 10 patients with submassive PE. Treatment parameters, PE attenuation, clot burden, computed tomography signs of right ventricle dysfunction and right ventricular systolic pressure at echocardiography were retrospectively analyzed to determine correlation with pulmonary artery pressure improvement using Spearman correlation. A single reader, blinded to the treatment results, measured PE attenuation of all patients. There was a significant positive correlation between PE attenuation and absolute pulmonary artery pressure improvement with a Spearman correlation of 0.741, p=0.014. When attenuation was greater than or equal to the median (44.5 HU, n=5), CDT was associated with significantly better pulmonary artery pressure improvement (p=0.037). Clot attenuation at CTPA may be a potential imaging biomarker for predicting pulmonary artery pressure improvement after CDT.
AB - This study examined the potential correlation between pulmonary embolism (PE) attenuation on computed tomography pulmonary angiography (CTPA) and pulmonary artery hemodynamic response to catheter-directed thrombolysis (CDT) in 10 patients with submassive PE. Treatment parameters, PE attenuation, clot burden, computed tomography signs of right ventricle dysfunction and right ventricular systolic pressure at echocardiography were retrospectively analyzed to determine correlation with pulmonary artery pressure improvement using Spearman correlation. A single reader, blinded to the treatment results, measured PE attenuation of all patients. There was a significant positive correlation between PE attenuation and absolute pulmonary artery pressure improvement with a Spearman correlation of 0.741, p=0.014. When attenuation was greater than or equal to the median (44.5 HU, n=5), CDT was associated with significantly better pulmonary artery pressure improvement (p=0.037). Clot attenuation at CTPA may be a potential imaging biomarker for predicting pulmonary artery pressure improvement after CDT.
KW - computed tomographic angiography (CTA)
KW - pulmonary embolism (PE)
KW - thrombolytic therapy
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U2 - 10.1177/1358863X18756504
DO - 10.1177/1358863X18756504
M3 - Article
C2 - 29498612
AN - SCOPUS:85045331862
VL - 23
SP - 134
EP - 138
JO - Vascular Medicine (United Kingdom)
JF - Vascular Medicine (United Kingdom)
SN - 1358-863X
IS - 2
ER -