Pulmonary carcinoid tumors with Cushing's syndrome: An aggressive variant or not?

Subrato J. Deb, Francis C. Nichols, Mark S. Allen, Claude Deschamps, Stephen D. Cassivi, Peter C. Pairolero, Sudhir R. Sundaresan, Giuseppe Cardillo, Joseph Shrager, Jean Deslauriers, Stephen C. Yang

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

Background. Adrenocorticotropic hormone (ACTH)-secreting pulmonary carcinoid is considered an aggressive variant of carcinoid tumors. Current knowledge is based upon a limited number of reports with few patients. Methods. All patients with Cushing's syndrome (CS) resulting from pulmonary carcinoid (PC) who underwent pulmonary resection at our institution from November 1966 through April 1998 were reviewed. Results. The group studied consisted of 10 males and 13 females. The median age was 39 years (range: 14-71). Pulmonary symptoms were present in 4 patients. Chest radiographs identified an abnormality in 13 patients (57%) and chest computerized tomography (CT) identified an abnormality in all 20 patients examined. Before pulmonary resection, hypophysectomy and bilateral adrenalectomy were performed in 7 patients (30%) each. Median time interval from presentation to pulmonary resection was 17 months (range: 1-228). Lobectomy was performed in 16 patients, segmentectomy was performed in 4 patients, and bilobectomy, pneumonectomy, and wedge excision was performed in 1 patient each. There were no operative deaths. Typical carcinoid was identified in 21 patients (91%) and atypical carcinoid was identified in 2 patients (9%). The median tumor diameter was 1.3 cm (range: 0.3-10). Nineteen patients (83%) underwent mediastinal lymphadenectomy and lymph node metastasis was found in 6 patients (32%) (N1 in 4 patients, N2 in 2 patients). The median follow-up was 78 months (range: 1-432). CS resolved in all of the patients. CS with PC recurred in 4 patients and CS alone recurred in 1 patient. Two patients underwent curative re-resection. Two patients, one with disseminated PC, died at last follow-up. Conclusions. Despite long delays in surgical therapy, pulmonary resection for ACTH-secreting PCs results in a favorable prognosis. Anatomic resection with complete mediastinal lymphadenectomy decreases local recurrence. Although rare these tumors do not seem to be as aggressive a variant of typical carcinoid tumors as previously reported.

Original languageEnglish (US)
Pages (from-to)1132-1136
Number of pages5
JournalAnnals of Thoracic Surgery
Volume79
Issue number4
DOIs
StatePublished - Apr 2005

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Cushing Syndrome
Carcinoid Tumor
Lung
Lymph Node Excision
Adrenocorticotropic Hormone
Thorax
Hypophysectomy
Segmental Mastectomy
Pneumonectomy

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Deb, S. J., Nichols, F. C., Allen, M. S., Deschamps, C., Cassivi, S. D., Pairolero, P. C., ... Yang, S. C. (2005). Pulmonary carcinoid tumors with Cushing's syndrome: An aggressive variant or not? Annals of Thoracic Surgery, 79(4), 1132-1136. https://doi.org/10.1016/j.athoracsur.2004.07.021

Pulmonary carcinoid tumors with Cushing's syndrome : An aggressive variant or not? / Deb, Subrato J.; Nichols, Francis C.; Allen, Mark S.; Deschamps, Claude; Cassivi, Stephen D.; Pairolero, Peter C.; Sundaresan, Sudhir R.; Cardillo, Giuseppe; Shrager, Joseph; Deslauriers, Jean; Yang, Stephen C.

In: Annals of Thoracic Surgery, Vol. 79, No. 4, 04.2005, p. 1132-1136.

Research output: Contribution to journalReview article

Deb, SJ, Nichols, FC, Allen, MS, Deschamps, C, Cassivi, SD, Pairolero, PC, Sundaresan, SR, Cardillo, G, Shrager, J, Deslauriers, J & Yang, SC 2005, 'Pulmonary carcinoid tumors with Cushing's syndrome: An aggressive variant or not?', Annals of Thoracic Surgery, vol. 79, no. 4, pp. 1132-1136. https://doi.org/10.1016/j.athoracsur.2004.07.021
Deb SJ, Nichols FC, Allen MS, Deschamps C, Cassivi SD, Pairolero PC et al. Pulmonary carcinoid tumors with Cushing's syndrome: An aggressive variant or not? Annals of Thoracic Surgery. 2005 Apr;79(4):1132-1136. https://doi.org/10.1016/j.athoracsur.2004.07.021
Deb, Subrato J. ; Nichols, Francis C. ; Allen, Mark S. ; Deschamps, Claude ; Cassivi, Stephen D. ; Pairolero, Peter C. ; Sundaresan, Sudhir R. ; Cardillo, Giuseppe ; Shrager, Joseph ; Deslauriers, Jean ; Yang, Stephen C. / Pulmonary carcinoid tumors with Cushing's syndrome : An aggressive variant or not?. In: Annals of Thoracic Surgery. 2005 ; Vol. 79, No. 4. pp. 1132-1136.
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title = "Pulmonary carcinoid tumors with Cushing's syndrome: An aggressive variant or not?",
abstract = "Background. Adrenocorticotropic hormone (ACTH)-secreting pulmonary carcinoid is considered an aggressive variant of carcinoid tumors. Current knowledge is based upon a limited number of reports with few patients. Methods. All patients with Cushing's syndrome (CS) resulting from pulmonary carcinoid (PC) who underwent pulmonary resection at our institution from November 1966 through April 1998 were reviewed. Results. The group studied consisted of 10 males and 13 females. The median age was 39 years (range: 14-71). Pulmonary symptoms were present in 4 patients. Chest radiographs identified an abnormality in 13 patients (57{\%}) and chest computerized tomography (CT) identified an abnormality in all 20 patients examined. Before pulmonary resection, hypophysectomy and bilateral adrenalectomy were performed in 7 patients (30{\%}) each. Median time interval from presentation to pulmonary resection was 17 months (range: 1-228). Lobectomy was performed in 16 patients, segmentectomy was performed in 4 patients, and bilobectomy, pneumonectomy, and wedge excision was performed in 1 patient each. There were no operative deaths. Typical carcinoid was identified in 21 patients (91{\%}) and atypical carcinoid was identified in 2 patients (9{\%}). The median tumor diameter was 1.3 cm (range: 0.3-10). Nineteen patients (83{\%}) underwent mediastinal lymphadenectomy and lymph node metastasis was found in 6 patients (32{\%}) (N1 in 4 patients, N2 in 2 patients). The median follow-up was 78 months (range: 1-432). CS resolved in all of the patients. CS with PC recurred in 4 patients and CS alone recurred in 1 patient. Two patients underwent curative re-resection. Two patients, one with disseminated PC, died at last follow-up. Conclusions. Despite long delays in surgical therapy, pulmonary resection for ACTH-secreting PCs results in a favorable prognosis. Anatomic resection with complete mediastinal lymphadenectomy decreases local recurrence. Although rare these tumors do not seem to be as aggressive a variant of typical carcinoid tumors as previously reported.",
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T2 - An aggressive variant or not?

AU - Deb, Subrato J.

AU - Nichols, Francis C.

AU - Allen, Mark S.

AU - Deschamps, Claude

AU - Cassivi, Stephen D.

AU - Pairolero, Peter C.

AU - Sundaresan, Sudhir R.

AU - Cardillo, Giuseppe

AU - Shrager, Joseph

AU - Deslauriers, Jean

AU - Yang, Stephen C.

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N2 - Background. Adrenocorticotropic hormone (ACTH)-secreting pulmonary carcinoid is considered an aggressive variant of carcinoid tumors. Current knowledge is based upon a limited number of reports with few patients. Methods. All patients with Cushing's syndrome (CS) resulting from pulmonary carcinoid (PC) who underwent pulmonary resection at our institution from November 1966 through April 1998 were reviewed. Results. The group studied consisted of 10 males and 13 females. The median age was 39 years (range: 14-71). Pulmonary symptoms were present in 4 patients. Chest radiographs identified an abnormality in 13 patients (57%) and chest computerized tomography (CT) identified an abnormality in all 20 patients examined. Before pulmonary resection, hypophysectomy and bilateral adrenalectomy were performed in 7 patients (30%) each. Median time interval from presentation to pulmonary resection was 17 months (range: 1-228). Lobectomy was performed in 16 patients, segmentectomy was performed in 4 patients, and bilobectomy, pneumonectomy, and wedge excision was performed in 1 patient each. There were no operative deaths. Typical carcinoid was identified in 21 patients (91%) and atypical carcinoid was identified in 2 patients (9%). The median tumor diameter was 1.3 cm (range: 0.3-10). Nineteen patients (83%) underwent mediastinal lymphadenectomy and lymph node metastasis was found in 6 patients (32%) (N1 in 4 patients, N2 in 2 patients). The median follow-up was 78 months (range: 1-432). CS resolved in all of the patients. CS with PC recurred in 4 patients and CS alone recurred in 1 patient. Two patients underwent curative re-resection. Two patients, one with disseminated PC, died at last follow-up. Conclusions. Despite long delays in surgical therapy, pulmonary resection for ACTH-secreting PCs results in a favorable prognosis. Anatomic resection with complete mediastinal lymphadenectomy decreases local recurrence. Although rare these tumors do not seem to be as aggressive a variant of typical carcinoid tumors as previously reported.

AB - Background. Adrenocorticotropic hormone (ACTH)-secreting pulmonary carcinoid is considered an aggressive variant of carcinoid tumors. Current knowledge is based upon a limited number of reports with few patients. Methods. All patients with Cushing's syndrome (CS) resulting from pulmonary carcinoid (PC) who underwent pulmonary resection at our institution from November 1966 through April 1998 were reviewed. Results. The group studied consisted of 10 males and 13 females. The median age was 39 years (range: 14-71). Pulmonary symptoms were present in 4 patients. Chest radiographs identified an abnormality in 13 patients (57%) and chest computerized tomography (CT) identified an abnormality in all 20 patients examined. Before pulmonary resection, hypophysectomy and bilateral adrenalectomy were performed in 7 patients (30%) each. Median time interval from presentation to pulmonary resection was 17 months (range: 1-228). Lobectomy was performed in 16 patients, segmentectomy was performed in 4 patients, and bilobectomy, pneumonectomy, and wedge excision was performed in 1 patient each. There were no operative deaths. Typical carcinoid was identified in 21 patients (91%) and atypical carcinoid was identified in 2 patients (9%). The median tumor diameter was 1.3 cm (range: 0.3-10). Nineteen patients (83%) underwent mediastinal lymphadenectomy and lymph node metastasis was found in 6 patients (32%) (N1 in 4 patients, N2 in 2 patients). The median follow-up was 78 months (range: 1-432). CS resolved in all of the patients. CS with PC recurred in 4 patients and CS alone recurred in 1 patient. Two patients underwent curative re-resection. Two patients, one with disseminated PC, died at last follow-up. Conclusions. Despite long delays in surgical therapy, pulmonary resection for ACTH-secreting PCs results in a favorable prognosis. Anatomic resection with complete mediastinal lymphadenectomy decreases local recurrence. Although rare these tumors do not seem to be as aggressive a variant of typical carcinoid tumors as previously reported.

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