Pulmonary alveolar proteinosis: High-resolution CT, chest radiographic, and functional correlations

Ki Nam Lee, David L. Levin, W. Richard Webb, Derong Chen, Maria L. Storto, Jeffrey A. Golden

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Study objective: To determine whether a correlation exists between pulmonary function and both frontal chest radiographs and high-resolution chest CT findings in patients with pulmonary alveolar proteinosis (PAP). Design: Retrospective review of radiographic and clinical data. Setting: Tertiary referral hospital. Patients: Seven patients with PAP were studied on 25 occasions using high-resolution chest CT (n=21), frontal chest radiographs (n=19), and pulmonary function tests (PFTs) (n=25). Measurements and results: Visual estimates of the extent, degree, and overall severity of parenchymal abnormalities were determined for plain radiographs and high-resolution chest CT, and were correlated with PFTs. With high-resolution CT, the extent and severity of ground-glass opacity correlated significantly with the presence of a restrictive ventilatory defect, reduced diffusing capacity, and hypoxemia. Chest radiographic findings also correlated significantly with restrictive ventilatory defect, diffusing capacity, and hypoxemia. Conclusion: In patients with PAP, although high-resolution CT correlates more closely with pulmonary function, plain radiographs should be sufficient for follow-up.

Original languageEnglish (US)
Pages (from-to)989-995
Number of pages7
JournalChest
Volume111
Issue number4
StatePublished - 1997
Externally publishedYes

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Pulmonary Alveolar Proteinosis
Thorax
Respiratory Function Tests
Lung
Tertiary Care Centers
Glass

Keywords

  • alveolar proteinosis
  • computed tomography
  • function test
  • lungs
  • pulmonary

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Lee, K. N., Levin, D. L., Webb, W. R., Chen, D., Storto, M. L., & Golden, J. A. (1997). Pulmonary alveolar proteinosis: High-resolution CT, chest radiographic, and functional correlations. Chest, 111(4), 989-995.

Pulmonary alveolar proteinosis : High-resolution CT, chest radiographic, and functional correlations. / Lee, Ki Nam; Levin, David L.; Webb, W. Richard; Chen, Derong; Storto, Maria L.; Golden, Jeffrey A.

In: Chest, Vol. 111, No. 4, 1997, p. 989-995.

Research output: Contribution to journalArticle

Lee, KN, Levin, DL, Webb, WR, Chen, D, Storto, ML & Golden, JA 1997, 'Pulmonary alveolar proteinosis: High-resolution CT, chest radiographic, and functional correlations', Chest, vol. 111, no. 4, pp. 989-995.
Lee KN, Levin DL, Webb WR, Chen D, Storto ML, Golden JA. Pulmonary alveolar proteinosis: High-resolution CT, chest radiographic, and functional correlations. Chest. 1997;111(4):989-995.
Lee, Ki Nam ; Levin, David L. ; Webb, W. Richard ; Chen, Derong ; Storto, Maria L. ; Golden, Jeffrey A. / Pulmonary alveolar proteinosis : High-resolution CT, chest radiographic, and functional correlations. In: Chest. 1997 ; Vol. 111, No. 4. pp. 989-995.
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AU - Golden, Jeffrey A.

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