Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon

Michael J. Ford, Michael Camilleri, Alan R. Zinsmeister, Russell B. Hanson

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Background & Aims: Psychosensory stimulation increases the perception of stimuli in different regions of the human colon. The aim of this study was to determine the perception of pain and gas during distention of two colonic regions in healthy volunteers during stress and relaxation. Methods: In 22 healthy subjects, phasic distentions of transverse and sigmoid colon were performed using infinitely compliant balloons, and symptoms were measured before and during one of three randomized treatments: sham or active relaxation or mental stress. Anxiety ratings and somatic cold-pain sensitivity were included in a multivariate regression model. Results: Mental stress increased levels of anxiety (P < 0.05) and the sensation of gas (P < 0.01), but not pain (P = NS), during transverse colon distentions and the sensations of gas and pain during sigmoid distentions (P < 0.05). Active relaxation reduced only sensation of gas in the sigmoid colon. Somatic pain sensitivity and pretreatment colonic sensory scores were significantly associated with the sensory scores during treatments. Conclusions: Psychosensory stimulation increases colonic sensation during short-term distention in two regions of the human colon; relaxation alone exerts a smaller influence on sensations arising in the sigmoid colon.

Original languageEnglish (US)
Pages (from-to)1772-1780
Number of pages9
JournalGastroenterology
Volume109
Issue number6
DOIs
StatePublished - 1995

Fingerprint

Transverse Colon
Sigmoid Colon
Gases
Nociceptive Pain
Healthy Volunteers
Colon
Anxiety
Pain
Pain Perception
Hypesthesia
Placebos
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon. / Ford, Michael J.; Camilleri, Michael; Zinsmeister, Alan R.; Hanson, Russell B.

In: Gastroenterology, Vol. 109, No. 6, 1995, p. 1772-1780.

Research output: Contribution to journalArticle

Ford, Michael J. ; Camilleri, Michael ; Zinsmeister, Alan R. ; Hanson, Russell B. / Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon. In: Gastroenterology. 1995 ; Vol. 109, No. 6. pp. 1772-1780.
@article{a6cc14326b854ff3bc2b9e17f5a1c26b,
title = "Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon",
abstract = "Background & Aims: Psychosensory stimulation increases the perception of stimuli in different regions of the human colon. The aim of this study was to determine the perception of pain and gas during distention of two colonic regions in healthy volunteers during stress and relaxation. Methods: In 22 healthy subjects, phasic distentions of transverse and sigmoid colon were performed using infinitely compliant balloons, and symptoms were measured before and during one of three randomized treatments: sham or active relaxation or mental stress. Anxiety ratings and somatic cold-pain sensitivity were included in a multivariate regression model. Results: Mental stress increased levels of anxiety (P < 0.05) and the sensation of gas (P < 0.01), but not pain (P = NS), during transverse colon distentions and the sensations of gas and pain during sigmoid distentions (P < 0.05). Active relaxation reduced only sensation of gas in the sigmoid colon. Somatic pain sensitivity and pretreatment colonic sensory scores were significantly associated with the sensory scores during treatments. Conclusions: Psychosensory stimulation increases colonic sensation during short-term distention in two regions of the human colon; relaxation alone exerts a smaller influence on sensations arising in the sigmoid colon.",
author = "Ford, {Michael J.} and Michael Camilleri and Zinsmeister, {Alan R.} and Hanson, {Russell B.}",
year = "1995",
doi = "10.1016/0016-5085(95)90743-2",
language = "English (US)",
volume = "109",
pages = "1772--1780",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon

AU - Ford, Michael J.

AU - Camilleri, Michael

AU - Zinsmeister, Alan R.

AU - Hanson, Russell B.

PY - 1995

Y1 - 1995

N2 - Background & Aims: Psychosensory stimulation increases the perception of stimuli in different regions of the human colon. The aim of this study was to determine the perception of pain and gas during distention of two colonic regions in healthy volunteers during stress and relaxation. Methods: In 22 healthy subjects, phasic distentions of transverse and sigmoid colon were performed using infinitely compliant balloons, and symptoms were measured before and during one of three randomized treatments: sham or active relaxation or mental stress. Anxiety ratings and somatic cold-pain sensitivity were included in a multivariate regression model. Results: Mental stress increased levels of anxiety (P < 0.05) and the sensation of gas (P < 0.01), but not pain (P = NS), during transverse colon distentions and the sensations of gas and pain during sigmoid distentions (P < 0.05). Active relaxation reduced only sensation of gas in the sigmoid colon. Somatic pain sensitivity and pretreatment colonic sensory scores were significantly associated with the sensory scores during treatments. Conclusions: Psychosensory stimulation increases colonic sensation during short-term distention in two regions of the human colon; relaxation alone exerts a smaller influence on sensations arising in the sigmoid colon.

AB - Background & Aims: Psychosensory stimulation increases the perception of stimuli in different regions of the human colon. The aim of this study was to determine the perception of pain and gas during distention of two colonic regions in healthy volunteers during stress and relaxation. Methods: In 22 healthy subjects, phasic distentions of transverse and sigmoid colon were performed using infinitely compliant balloons, and symptoms were measured before and during one of three randomized treatments: sham or active relaxation or mental stress. Anxiety ratings and somatic cold-pain sensitivity were included in a multivariate regression model. Results: Mental stress increased levels of anxiety (P < 0.05) and the sensation of gas (P < 0.01), but not pain (P = NS), during transverse colon distentions and the sensations of gas and pain during sigmoid distentions (P < 0.05). Active relaxation reduced only sensation of gas in the sigmoid colon. Somatic pain sensitivity and pretreatment colonic sensory scores were significantly associated with the sensory scores during treatments. Conclusions: Psychosensory stimulation increases colonic sensation during short-term distention in two regions of the human colon; relaxation alone exerts a smaller influence on sensations arising in the sigmoid colon.

UR - http://www.scopus.com/inward/record.url?scp=0028790117&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028790117&partnerID=8YFLogxK

U2 - 10.1016/0016-5085(95)90743-2

DO - 10.1016/0016-5085(95)90743-2

M3 - Article

VL - 109

SP - 1772

EP - 1780

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 6

ER -