Psychiatric manifestations of voltage-gated potassium-channel complex autoimmunity

Kristin J. Somers, Vanda A. Lennon, James R. Rundell, Sean J. Pittock, Daniel A. Drubach, Max R. Trenerry, Daniel H. Lachance, Christopher J. Klein, Paula A. Aston, Andrew McKeon

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


The authors describe the neuropsychiatric spectrum of voltage-gated potassium-channel complex (VGKC) autoimmunity among 67 seropositive patients; 2 had initially been assigned a primary psychiatric diagnosis. Diverse manifestations were recorded, often affective-predominant. Symptoms for 24 patients with florid presentations included confusion, 92%; memory impairment, 75%; personality change, 58%; depression, 33%; and anxiety, 29%. Of 15 who received immunotherapy, 67% improved. Forty-three patients with milder presentations or low positive VGKC complex Ab values are also described. Neuropsychiatric presentations were significantly associated with higher autoantibody values. Improvements were most evident in patients treated early, which emphasizes the need for early diagnosis and immunotherapy initiation.

Original languageEnglish (US)
Pages (from-to)425-433
Number of pages9
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number4
StatePublished - Jan 1 2011

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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