Psychiatric manifestations of voltage-gated potassium-channel complex autoimmunity

Kristin J. Somers; Vanda A. Lennon; James R. Rundell; Sean J. Pittock; Daniel A. Drubach; Max R. Trenerry; Daniel H. Lachance; Christopher J. Klein; Paula A. Aston; Andrew McKeon

doi:10.1176/jnp.23.4.jnp425

Psychiatric manifestations of voltage-gated potassium-channel complex autoimmunity

Kristin J. Somers, Vanda A. Lennon, James R. Rundell, Sean J. Pittock, Daniel A. Drubach, Max R. Trenerry, Daniel H. Lachance, Christopher J. Klein, Paula A. Aston, Andrew McKeon

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The authors describe the neuropsychiatric spectrum of voltage-gated potassium-channel complex (VGKC) autoimmunity among 67 seropositive patients; 2 had initially been assigned a primary psychiatric diagnosis. Diverse manifestations were recorded, often affective-predominant. Symptoms for 24 patients with florid presentations included confusion, 92%; memory impairment, 75%; personality change, 58%; depression, 33%; and anxiety, 29%. Of 15 who received immunotherapy, 67% improved. Forty-three patients with milder presentations or low positive VGKC complex Ab values are also described. Neuropsychiatric presentations were significantly associated with higher autoantibody values. Improvements were most evident in patients treated early, which emphasizes the need for early diagnosis and immunotherapy initiation.

Original language	English (US)
Pages (from-to)	425-433
Number of pages	9
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	23
Issue number	4
DOIs	https://doi.org/10.1176/jnp.23.4.jnp425
State	Published - Jan 1 2011

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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title = "Psychiatric manifestations of voltage-gated potassium-channel complex autoimmunity",

abstract = "The authors describe the neuropsychiatric spectrum of voltage-gated potassium-channel complex (VGKC) autoimmunity among 67 seropositive patients; 2 had initially been assigned a primary psychiatric diagnosis. Diverse manifestations were recorded, often affective-predominant. Symptoms for 24 patients with florid presentations included confusion, 92%; memory impairment, 75%; personality change, 58%; depression, 33%; and anxiety, 29%. Of 15 who received immunotherapy, 67% improved. Forty-three patients with milder presentations or low positive VGKC complex Ab values are also described. Neuropsychiatric presentations were significantly associated with higher autoantibody values. Improvements were most evident in patients treated early, which emphasizes the need for early diagnosis and immunotherapy initiation.",

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AU - Drubach, Daniel A.

AU - Trenerry, Max R.

AU - Lachance, Daniel H.

AU - Klein, Christopher J.

AU - Aston, Paula A.

AU - McKeon, Andrew

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Psychiatric manifestations of voltage-gated potassium-channel complex autoimmunity

Abstract

ASJC Scopus subject areas

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