TY - JOUR
T1 - Psychiatric history and related exposures as risk factors foralzheimer’s disease
T2 - A collaborativere-analysis of case-control studies
AU - A Hofman For The Eurodem Risk Factors Research Group
AU - Jorm, A. F.
AU - Van Duijn, C. M.
AU - Chandra, V.
AU - Fratiglioni, L.
AU - Graves, A.
AU - Heyman, A.
AU - Kokmen, E.
AU - Kondo,
AU - Mortimer, J. A.
AU - Rocca, W. A.
AU - Shalat, S. L.
AU - Soininen, H.
AU - Hofman, A.
PY - 1991
Y1 - 1991
N2 - Data from case-control studies of Alzheimer’s disease (AD) were pooled to examine the possible roles of history of depression, anti-depressant treatment and adverse life events as risk factors. History of depression was found to beassociated with AD, although the effect was confined to late onset cases. The association held for episodes of depression more than 10 years before AD onset, as well as for episodes occurring within a decade of onset. No associationwas found with anti-depressant treatment. However, data were only available from two studies, limiting the power ofthe analysis. Also, no association was found with the three major life events considered in the pooled analysis: Deathof spouse, death of a child and divorce.
AB - Data from case-control studies of Alzheimer’s disease (AD) were pooled to examine the possible roles of history of depression, anti-depressant treatment and adverse life events as risk factors. History of depression was found to beassociated with AD, although the effect was confined to late onset cases. The association held for episodes of depression more than 10 years before AD onset, as well as for episodes occurring within a decade of onset. No associationwas found with anti-depressant treatment. However, data were only available from two studies, limiting the power ofthe analysis. Also, no association was found with the three major life events considered in the pooled analysis: Deathof spouse, death of a child and divorce.
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U2 - 10.1093/ije/20.Supplement_2.S43
DO - 10.1093/ije/20.Supplement_2.S43
M3 - Article
C2 - 1917269
AN - SCOPUS:0025738238
SN - 0300-5771
VL - 20
SP - S43-S47
JO - International journal of epidemiology
JF - International journal of epidemiology
ER -