Psychiatric history and related exposures as risk factors for Alzheimer's disease: A collaborative re-analysis of case-control studies

A. F. Jorm, C. M. Van Duijn, V. Chandra, L. Fratiglioni, A. B. Graves, A. Heyman, E. Kokmen, K. Kondo, J. A. Mortimer, Walter A Rocca, S. L. Shalat, H. Soininen, A. Hofman

Research output: Contribution to journalArticle

215 Citations (Scopus)

Abstract

Data from case-control studies of Alzheimer's disease (AD) were pooled to examine the possible roles of history of depression, anti-depressant treatment and adverse life events as risk factors. History of depression was found to be associated with AD, although the effect was confined to late onset cases. The association held for episodes of depression more than 10 years before AD onset, as well as for episodes occurring within a decade of onset. No association was found with anti-depressant treatment. However, data were only available from two studies, limiting the power of the analysis. Also, no association was found with the three major life events considered in the pooled analysis: death of spouse, death of a child and divorce.

Original languageEnglish (US)
JournalInternational Journal of Epidemiology
Volume20
Issue numberSUPPL. 2
StatePublished - 1991
Externally publishedYes

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Psychiatry
Case-Control Studies
Alzheimer Disease
Depression
Divorce
Spouses
Therapeutics
Power (Psychology)

ASJC Scopus subject areas

  • Epidemiology

Cite this

Jorm, A. F., Van Duijn, C. M., Chandra, V., Fratiglioni, L., Graves, A. B., Heyman, A., ... Hofman, A. (1991). Psychiatric history and related exposures as risk factors for Alzheimer's disease: A collaborative re-analysis of case-control studies. International Journal of Epidemiology, 20(SUPPL. 2).

Psychiatric history and related exposures as risk factors for Alzheimer's disease : A collaborative re-analysis of case-control studies. / Jorm, A. F.; Van Duijn, C. M.; Chandra, V.; Fratiglioni, L.; Graves, A. B.; Heyman, A.; Kokmen, E.; Kondo, K.; Mortimer, J. A.; Rocca, Walter A; Shalat, S. L.; Soininen, H.; Hofman, A.

In: International Journal of Epidemiology, Vol. 20, No. SUPPL. 2, 1991.

Research output: Contribution to journalArticle

Jorm, AF, Van Duijn, CM, Chandra, V, Fratiglioni, L, Graves, AB, Heyman, A, Kokmen, E, Kondo, K, Mortimer, JA, Rocca, WA, Shalat, SL, Soininen, H & Hofman, A 1991, 'Psychiatric history and related exposures as risk factors for Alzheimer's disease: A collaborative re-analysis of case-control studies', International Journal of Epidemiology, vol. 20, no. SUPPL. 2.
Jorm, A. F. ; Van Duijn, C. M. ; Chandra, V. ; Fratiglioni, L. ; Graves, A. B. ; Heyman, A. ; Kokmen, E. ; Kondo, K. ; Mortimer, J. A. ; Rocca, Walter A ; Shalat, S. L. ; Soininen, H. ; Hofman, A. / Psychiatric history and related exposures as risk factors for Alzheimer's disease : A collaborative re-analysis of case-control studies. In: International Journal of Epidemiology. 1991 ; Vol. 20, No. SUPPL. 2.
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AU - Fratiglioni, L.

AU - Graves, A. B.

AU - Heyman, A.

AU - Kokmen, E.

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AU - Mortimer, J. A.

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