Psychiatric Disorders in Mothers of Children with Attention-Deficit/Hyperactivity Disorder: A Population-Based Perspective

Kendra J. Homan, William J. Barbaresi, Michael W. Mellon, Amy L. Weaver, Jill M. Killian, Amanda R. Lucchetti, Slavica K Katusic

Research output: Contribution to journalArticle

Abstract

Objectives: The purpose of this study was to conduct a long-term, population-based, epidemiologic study of psychiatric disorders in mothers of children with attention-deficit/hyperactivity disorder (ADHD). Methods: Subjects included mothers of 306 childhood incident cases of ADHD and mothers of 617 age/gender matched controls from a 1976–1982 birth cohort. Results: Compared to mothers of controls, mothers of children with ADHD were significantly more likely to be diagnosed prior to the child’s birth with a depressive disorder (adjusted odds ratio (aOR), 3.1; 95% confidence interval (CI), 1.3–7.7), an adjustment disorder (aOR, 8.1; 95% CI, 1.7–39.5), or any psychiatric disorder (aOR, 2.5; 95% CI, 1.61–4.7) and were likewise significantly more likely to be diagnosed with a de novo (i.e., first diagnosed after the child’s birth) depressive disorder (adjusted hazard ratio (aHR), 1.7; 95% CI, 1.2–2.4), de novo adjustment disorder (aHR, 2.0; 95% CI, 1.4–2.7), or any de novo psychiatric disorder (aHR, 1.7; 95% CI, 1.4–2.2) during the 21 years after the child’s birth. Conclusions: This study provides an opportunity to study the natural occurrence of psychiatric disorders in mothers of children with ADHD and suggests that the likelihood of having a child with ADHD is associated with maternal psychopathology both before and after the birth. This adds to existing knowledge of maternal psychopathology for children with ADHD and has implications for screening and monitoring. Future research is needed to clarify the role that both genetic and environmental risk factors play in the increased rates of psychopathology in mothers of children with ADHD.

Original languageEnglish (US)
JournalJournal of Child and Family Studies
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

ADHD
Attention Deficit Disorder with Hyperactivity
Psychiatry
Mothers
confidence
Confidence Intervals
Population
Parturition
psychopathology
Psychopathology
Adjustment Disorders
Odds Ratio
Depressive Disorder
Epidemiologic Studies
incident
childhood
monitoring
gender

Keywords

  • Attention-deficit/hyperactivity disorder
  • Birth cohort
  • Epidemiology
  • Maternal psychopathology
  • Psychiatric disorders

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Life-span and Life-course Studies

Cite this

Psychiatric Disorders in Mothers of Children with Attention-Deficit/Hyperactivity Disorder : A Population-Based Perspective. / Homan, Kendra J.; Barbaresi, William J.; Mellon, Michael W.; Weaver, Amy L.; Killian, Jill M.; Lucchetti, Amanda R.; Katusic, Slavica K.

In: Journal of Child and Family Studies, 01.01.2019.

Research output: Contribution to journalArticle

Homan, Kendra J. ; Barbaresi, William J. ; Mellon, Michael W. ; Weaver, Amy L. ; Killian, Jill M. ; Lucchetti, Amanda R. ; Katusic, Slavica K. / Psychiatric Disorders in Mothers of Children with Attention-Deficit/Hyperactivity Disorder : A Population-Based Perspective. In: Journal of Child and Family Studies. 2019.
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title = "Psychiatric Disorders in Mothers of Children with Attention-Deficit/Hyperactivity Disorder: A Population-Based Perspective",
abstract = "Objectives: The purpose of this study was to conduct a long-term, population-based, epidemiologic study of psychiatric disorders in mothers of children with attention-deficit/hyperactivity disorder (ADHD). Methods: Subjects included mothers of 306 childhood incident cases of ADHD and mothers of 617 age/gender matched controls from a 1976–1982 birth cohort. Results: Compared to mothers of controls, mothers of children with ADHD were significantly more likely to be diagnosed prior to the child’s birth with a depressive disorder (adjusted odds ratio (aOR), 3.1; 95{\%} confidence interval (CI), 1.3–7.7), an adjustment disorder (aOR, 8.1; 95{\%} CI, 1.7–39.5), or any psychiatric disorder (aOR, 2.5; 95{\%} CI, 1.61–4.7) and were likewise significantly more likely to be diagnosed with a de novo (i.e., first diagnosed after the child’s birth) depressive disorder (adjusted hazard ratio (aHR), 1.7; 95{\%} CI, 1.2–2.4), de novo adjustment disorder (aHR, 2.0; 95{\%} CI, 1.4–2.7), or any de novo psychiatric disorder (aHR, 1.7; 95{\%} CI, 1.4–2.2) during the 21 years after the child’s birth. Conclusions: This study provides an opportunity to study the natural occurrence of psychiatric disorders in mothers of children with ADHD and suggests that the likelihood of having a child with ADHD is associated with maternal psychopathology both before and after the birth. This adds to existing knowledge of maternal psychopathology for children with ADHD and has implications for screening and monitoring. Future research is needed to clarify the role that both genetic and environmental risk factors play in the increased rates of psychopathology in mothers of children with ADHD.",
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AU - Homan, Kendra J.

AU - Barbaresi, William J.

AU - Mellon, Michael W.

AU - Weaver, Amy L.

AU - Killian, Jill M.

AU - Lucchetti, Amanda R.

AU - Katusic, Slavica K

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N2 - Objectives: The purpose of this study was to conduct a long-term, population-based, epidemiologic study of psychiatric disorders in mothers of children with attention-deficit/hyperactivity disorder (ADHD). Methods: Subjects included mothers of 306 childhood incident cases of ADHD and mothers of 617 age/gender matched controls from a 1976–1982 birth cohort. Results: Compared to mothers of controls, mothers of children with ADHD were significantly more likely to be diagnosed prior to the child’s birth with a depressive disorder (adjusted odds ratio (aOR), 3.1; 95% confidence interval (CI), 1.3–7.7), an adjustment disorder (aOR, 8.1; 95% CI, 1.7–39.5), or any psychiatric disorder (aOR, 2.5; 95% CI, 1.61–4.7) and were likewise significantly more likely to be diagnosed with a de novo (i.e., first diagnosed after the child’s birth) depressive disorder (adjusted hazard ratio (aHR), 1.7; 95% CI, 1.2–2.4), de novo adjustment disorder (aHR, 2.0; 95% CI, 1.4–2.7), or any de novo psychiatric disorder (aHR, 1.7; 95% CI, 1.4–2.2) during the 21 years after the child’s birth. Conclusions: This study provides an opportunity to study the natural occurrence of psychiatric disorders in mothers of children with ADHD and suggests that the likelihood of having a child with ADHD is associated with maternal psychopathology both before and after the birth. This adds to existing knowledge of maternal psychopathology for children with ADHD and has implications for screening and monitoring. Future research is needed to clarify the role that both genetic and environmental risk factors play in the increased rates of psychopathology in mothers of children with ADHD.

AB - Objectives: The purpose of this study was to conduct a long-term, population-based, epidemiologic study of psychiatric disorders in mothers of children with attention-deficit/hyperactivity disorder (ADHD). Methods: Subjects included mothers of 306 childhood incident cases of ADHD and mothers of 617 age/gender matched controls from a 1976–1982 birth cohort. Results: Compared to mothers of controls, mothers of children with ADHD were significantly more likely to be diagnosed prior to the child’s birth with a depressive disorder (adjusted odds ratio (aOR), 3.1; 95% confidence interval (CI), 1.3–7.7), an adjustment disorder (aOR, 8.1; 95% CI, 1.7–39.5), or any psychiatric disorder (aOR, 2.5; 95% CI, 1.61–4.7) and were likewise significantly more likely to be diagnosed with a de novo (i.e., first diagnosed after the child’s birth) depressive disorder (adjusted hazard ratio (aHR), 1.7; 95% CI, 1.2–2.4), de novo adjustment disorder (aHR, 2.0; 95% CI, 1.4–2.7), or any de novo psychiatric disorder (aHR, 1.7; 95% CI, 1.4–2.2) during the 21 years after the child’s birth. Conclusions: This study provides an opportunity to study the natural occurrence of psychiatric disorders in mothers of children with ADHD and suggests that the likelihood of having a child with ADHD is associated with maternal psychopathology both before and after the birth. This adds to existing knowledge of maternal psychopathology for children with ADHD and has implications for screening and monitoring. Future research is needed to clarify the role that both genetic and environmental risk factors play in the increased rates of psychopathology in mothers of children with ADHD.

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KW - Epidemiology

KW - Maternal psychopathology

KW - Psychiatric disorders

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