Pseudoporphyria: A clinical and biochemical study of 20 patients

Carl F. Schanbacher, Erin R. Vanness, Mazen S. Daoud, Ayalew Tefferi, W. P. Daniel

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

• Objective: To describe the clinical and laboratory findings in patients with pseudoporphyria. • Patients and Methods: This retrospective review identified 261 patients with either porphyrin metabolism abnormalities or pseudoporphyria who were seen at the Mayo Clinic in Rochester, Minn, between 1992 and 1996. All patients with documented porphyria cutanea tarda (PCT), noncutaneous porphyrias, or variegate porphyria were excluded. • Results: Twenty patients had active cutaneous lesions resembling, PCT with no diagnostic laboratory abnormalihepatitis B or C. In all 20 patients, porphyrin profiles were nondiagnostic. Of 16 patients for whom follow-up was available, 11 reported persistent symptoms for a mean of 2.5 years after evaluation. Five patients were free of symptoms 1 week to 6 months after discontinuation of the presumed offending agent. • Conclusion: Pseudoporphyria mimics the cutaneous symptoms of PCT in the setting of normal or near-normal porphyrin levels in the serum, urine, or stool. Despite efforts to discontinue an offending medication, symptoms may persist indefinitely.

Original languageEnglish (US)
Article number62914
Pages (from-to)488-492
Number of pages5
JournalMayo Clinic proceedings
Volume76
Issue number5
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Medicine(all)

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