PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells

Chemical Compounds

• Bortezomib 100%
• Tiron 58%
• Depolarization 44%
• Bongkrekic Acid 34%
• Permeability 31%
• Apoptosis Induction 29%
• Small Interfering RNA 27%
• Protein 24%
• Confocal Microscopy 22%
• Radical Scavenger 22%
• Reactive Oxygen Metabolite 18%
• Antitumor 18%
• Cytochrome 17%
• Free Radical 15%
• Cleavage 13%
• Pore 13%
• Fluorescence 11%

Medicine & Life Sciences

• Caspase 2 90%
• Cathepsin B 77%
• Bortezomib 73%
• Pancreatic Neoplasms 56%
• Apoptosis 36%
• Ketones 18%
• 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt 16%
• Bongkrekic Acid 8%
• mitochondrial permeability transition pore 6%
• Free Radical Scavengers 6%
• Caspase Inhibitors 6%
• Pancreatic Carcinoma 6%
• Phosphatidylserines 5%
• Proteins 5%
• Cytochromes c 5%
• Lysosomes 5%
• Fluorescence Microscopy 4%
• Cytosol 4%
• Confocal Microscopy 4%
• Permeability 4%
• Small Interfering RNA 4%
• Reactive Oxygen Species 3%
• Pharmacology 3%
• Cell Line 2%
• Messenger RNA 2%