Abstract
Importance of the field: Chronic constipation has a high prevalence, and current medical and pharmacological therapies do not restore normal bowel function in all patients. Areas covered in the review: A PubMed search (1965 - 2009) using the following terms alone or in combination: prucalopride, 5-HT 4, R093877, safety, toxicity, pharmacokinetics, pharmacodynamics, transit, cardiac, hERG, arrhythmia, potassium current, elderly. What the reader will gain: Understanding of the mechanisms of action, safety, efficacy and indications for prucalopride in patients with chronic constipation. Take home message: Prucalopride is an efficacious and generally safe, new therapeutic option in the management of chronic constipation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 451-461 |
| Number of pages | 11 |
| Journal | Expert Opinion on Pharmacotherapy |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 2010 |
Keywords
- 5-HT receptor
- Efficacy
- Enterokinetic
- Pharmacodynamics
- Pharmacokinetics
- Prokinetic
- R093887
- R108512
- Safety
- Serotonin agonist
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)