Prucalopride for constipation

Michael Camilleri, Annemie Deiteren

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Importance of the field: Chronic constipation has a high prevalence, and current medical and pharmacological therapies do not restore normal bowel function in all patients. Areas covered in the review: A PubMed search (1965 - 2009) using the following terms alone or in combination: prucalopride, 5-HT 4, R093877, safety, toxicity, pharmacokinetics, pharmacodynamics, transit, cardiac, hERG, arrhythmia, potassium current, elderly. What the reader will gain: Understanding of the mechanisms of action, safety, efficacy and indications for prucalopride in patients with chronic constipation. Take home message: Prucalopride is an efficacious and generally safe, new therapeutic option in the management of chronic constipation.

Original languageEnglish (US)
Pages (from-to)451-461
Number of pages11
JournalExpert Opinion on Pharmacotherapy
Volume11
Issue number3
DOIs
StatePublished - Feb 1 2010

Keywords

  • 5-HT receptor
  • Efficacy
  • Enterokinetic
  • Pharmacodynamics
  • Pharmacokinetics
  • Prokinetic
  • R093887
  • R108512
  • Safety
  • Serotonin agonist

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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