Proximal tlibular dysfunction associated with tenofovir and didanosine causing fanconl syndrome and diabetes insipidus: A report of 3 cases

Joan M. Irizarry-Alvarado, Jamie P. Dwyer, Lisa M. Brumble, Salvador Alvarez, Julio C. Mendez

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

We report 3 cases of patients with HIV/AIDS in whom Fanconi syndrome and nephrogenic diabetes insipidus developed secondary to use of an antiretroviral regimen containing tenofovir disoproxil fumarate and didanosine. These patients presented with a history of polydipsia, polyuria, weight loss, anorexia, and wasting. Interestingly, 1 patient was not taking protease inhibitors. This response is a well- documented yet uncommon complication of tenofovir use in the HIV population. We recommend continued monitoring for renal toxicity when using the NRTI combination of tenofovir and didanosine.

Original languageEnglish (US)
Pages (from-to)114-121
Number of pages8
JournalAIDS Reader
Volume19
Issue number3
StatePublished - Apr 6 2009

Keywords

  • Antiretroviral therapy
  • Diabetes
  • Didanosine
  • Fanconi syndrome
  • HIV/AIDS
  • Kidney disease
  • NRTIs
  • Tenofovir

ASJC Scopus subject areas

  • Infectious Diseases

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