Proximal tlibular dysfunction associated with tenofovir and didanosine causing fanconl syndrome and diabetes insipidus: A report of 3 cases

We report 3 cases of patients with HIV/AIDS in whom Fanconi syndrome and nephrogenic diabetes insipidus developed secondary to use of an antiretroviral regimen containing tenofovir disoproxil fumarate and didanosine. These patients presented with a history of polydipsia, polyuria, weight loss, anorexia, and wasting. Interestingly, 1 patient was not taking protease inhibitors. This response is a well- documented yet uncommon complication of tenofovir use in the HIV population. We recommend continued monitoring for renal toxicity when using the NRTI combination of tenofovir and didanosine.