Provocative testing in inherited arrhythmias

Wataru Shimizu, Michael John Ackerman

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Heritable channelopathies that include congenital long QT syndrome (LQTS), Brugada syndrome (BrS), and catecholaminergic polymorphic ven tricular tachycardia (CPVT) affect an estimated 1 in 2000 persons, may present with syncope or sudden cardiac death, and often elude detection by standard 12-lead electrocardiography (ECG). In LQTS, an estimated 40% of genetically affected subjects have concealed LQTS with a normal or borderline heart rate corrected QT interval (QTc) at rest. A significant proportion of patients with BrS has concealed BrS with no evidence of a type 1 Brugada electrocardiographic pattern at rest. Every patient with CPVT has a normal resting ECG. Provocative testing with catecholamines and pharmacological testing with sodium channel blockers are critical diagnostic tests in the evaluation of these channelopathies and can help unmask LQTS, BrS, and CPVT in their concealed state. The role of these provocative tests in the evaluation of inherited arrhythmia syndromes will be reviewed in this chapter.

Original languageEnglish (US)
Title of host publicationElectrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention
PublisherSpringer London
Pages424-433
Number of pages10
ISBN (Print)9781846288531
DOIs
StatePublished - 2008

Fingerprint

Brugada Syndrome
Long QT Syndrome
Cardiac Arrhythmias
Tachycardia
Channelopathies
Electrocardiography
Sodium Channel Blockers
Sudden Cardiac Death
Syncope
Routine Diagnostic Tests
Catecholamines
Heart Rate
Pharmacology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Shimizu, W., & Ackerman, M. J. (2008). Provocative testing in inherited arrhythmias. In Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention (pp. 424-433). Springer London. https://doi.org/10.1007/978-1-84628-854-8_29

Provocative testing in inherited arrhythmias. / Shimizu, Wataru; Ackerman, Michael John.

Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London, 2008. p. 424-433.

Research output: Chapter in Book/Report/Conference proceedingChapter

Shimizu, W & Ackerman, MJ 2008, Provocative testing in inherited arrhythmias. in Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London, pp. 424-433. https://doi.org/10.1007/978-1-84628-854-8_29
Shimizu W, Ackerman MJ. Provocative testing in inherited arrhythmias. In Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London. 2008. p. 424-433 https://doi.org/10.1007/978-1-84628-854-8_29
Shimizu, Wataru ; Ackerman, Michael John. / Provocative testing in inherited arrhythmias. Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London, 2008. pp. 424-433
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