Prototyping CRISP: A causal relation and inference search platform applied to colorectal cancer data

Samuel Budd, Arno Blaas, Adrienne Hoarfrost, Kia Khezeli, Krittika D’Silva, Frank Soboczenski, Graham Mackintosh, Nicholas Chia, John Kalantari

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We introduce CRISP, a Causal Research and Inference Search Platform. It is designed to assist biological and medical research by applying a variety of causal discovery methods to heterogeneous and high-dimensional observational data. CRISP aims to identify a small set of input variables which are most likely to have a causal effect on a target variable. The output of CRISP, thus, highlights the most promising candidates for further targeted research. We illustrate the utility of CRISP with a case study in oncology, using a multi-omic colorectal cancer data set to identify causal drivers differentiating two subtypes of colorectal cancer.

Original languageEnglish (US)
Title of host publicationLifeTech 2021 - 2021 IEEE 3rd Global Conference on Life Sciences and Technologies
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages517-521
Number of pages5
ISBN (Electronic)9781665418751
DOIs
StatePublished - Mar 9 2021
Event3rd IEEE Global Conference on Life Sciences and Technologies, LifeTech 2021 - Nara, Japan
Duration: Mar 9 2021Mar 11 2021

Publication series

NameLifeTech 2021 - 2021 IEEE 3rd Global Conference on Life Sciences and Technologies

Conference

Conference3rd IEEE Global Conference on Life Sciences and Technologies, LifeTech 2021
Country/TerritoryJapan
CityNara
Period3/9/213/11/21

Keywords

  • Causal discovery
  • Causal inference
  • Colorectal cancer

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health(social science)
  • Biochemistry
  • Artificial Intelligence
  • Computer Science Applications

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