Proteome analysis of antiproliferative mechanism of 12-O- tetradecanoylphorbol 13-acetate on cultured nasopharyngeal carcinoma CNE2 cells

Peizhou Jiang; Ming Gan; Hua Huang; Xinming Shen; Shuang Wang; Kaitai Yao

doi:10.1021/pr0497677

Proteome analysis of antiproliferative mechanism of 12-O- tetradecanoylphorbol 13-acetate on cultured nasopharyngeal carcinoma CNE2 cells

Peizhou Jiang, Ming Gan, Hua Huang, Xinming Shen, Shuang Wang, Kaitai Yao

Neuroscience

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

12-O-Tetradecanoyl-phorbol-15-acetate (TPA) is a plant derivative with multiple function as tumor promoter, differentiation revulsant or leukemia therapy drug. The molecular mechanism of its function is perplexing. Many studies have focused on the mechanism of TPA stimulation in tumor promotion of mouse models or terminal differentiation of leukemia cells, but the effect of TPA on nasopharyngeal carcinoma (NPC) remains unclear, while TPA was considered to be associated with NPC development. In the present study, we employed proteomics techniques to study protein changes of a poorly differentiated squamous carcinoma cell line-CNE2 of human NPCs cells induced by TPA. Six significantly and reproducibly changed proteins were identified and their functional implications were discussed in some details.

Original language	English (US)
Pages (from-to)	599-605
Number of pages	7
Journal	Journal of Proteome Research
Volume	4
Issue number	2
DOIs	https://doi.org/10.1021/pr0497677
State	Published - Mar 2005

Keywords

12-O-tetradecanoyl-phorbol-13-acetate
Apoptosis
Nasopharyngeal carcinoma
Proteomics

ASJC Scopus subject areas

General Chemistry
Biochemistry

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10.1021/pr0497677

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title = "Proteome analysis of antiproliferative mechanism of 12-O- tetradecanoylphorbol 13-acetate on cultured nasopharyngeal carcinoma CNE2 cells",

abstract = "12-O-Tetradecanoyl-phorbol-15-acetate (TPA) is a plant derivative with multiple function as tumor promoter, differentiation revulsant or leukemia therapy drug. The molecular mechanism of its function is perplexing. Many studies have focused on the mechanism of TPA stimulation in tumor promotion of mouse models or terminal differentiation of leukemia cells, but the effect of TPA on nasopharyngeal carcinoma (NPC) remains unclear, while TPA was considered to be associated with NPC development. In the present study, we employed proteomics techniques to study protein changes of a poorly differentiated squamous carcinoma cell line-CNE2 of human NPCs cells induced by TPA. Six significantly and reproducibly changed proteins were identified and their functional implications were discussed in some details.",

keywords = "12-O-tetradecanoyl-phorbol-13-acetate, Apoptosis, Nasopharyngeal carcinoma, Proteomics",

author = "Peizhou Jiang and Ming Gan and Hua Huang and Xinming Shen and Shuang Wang and Kaitai Yao",

year = "2005",

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T1 - Proteome analysis of antiproliferative mechanism of 12-O- tetradecanoylphorbol 13-acetate on cultured nasopharyngeal carcinoma CNE2 cells

AU - Jiang, Peizhou

AU - Gan, Ming

AU - Huang, Hua

AU - Shen, Xinming

AU - Wang, Shuang

AU - Yao, Kaitai

PY - 2005/3

Y1 - 2005/3

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KW - Nasopharyngeal carcinoma

KW - Proteomics

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Proteome analysis of antiproliferative mechanism of 12-O- tetradecanoylphorbol 13-acetate on cultured nasopharyngeal carcinoma CNE2 cells

Abstract

Keywords

ASJC Scopus subject areas

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