Proteome analysis of antiproliferative mechanism of 12-O- tetradecanoylphorbol 13-acetate on cultured nasopharyngeal carcinoma CNE2 cells

Peizhou Jiang, Ming Gan, Hua Huang, Xinming Shen, Shuang Wang, Kaitai Yao

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

12-O-Tetradecanoyl-phorbol-15-acetate (TPA) is a plant derivative with multiple function as tumor promoter, differentiation revulsant or leukemia therapy drug. The molecular mechanism of its function is perplexing. Many studies have focused on the mechanism of TPA stimulation in tumor promotion of mouse models or terminal differentiation of leukemia cells, but the effect of TPA on nasopharyngeal carcinoma (NPC) remains unclear, while TPA was considered to be associated with NPC development. In the present study, we employed proteomics techniques to study protein changes of a poorly differentiated squamous carcinoma cell line-CNE2 of human NPCs cells induced by TPA. Six significantly and reproducibly changed proteins were identified and their functional implications were discussed in some details.

Original languageEnglish (US)
Pages (from-to)599-605
Number of pages7
JournalJournal of Proteome Research
Volume4
Issue number2
DOIs
StatePublished - Mar 1 2005

Keywords

  • 12-O-tetradecanoyl-phorbol-13-acetate
  • Apoptosis
  • Nasopharyngeal carcinoma
  • Proteomics

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Proteome analysis of antiproliferative mechanism of 12-O- tetradecanoylphorbol 13-acetate on cultured nasopharyngeal carcinoma CNE2 cells'. Together they form a unique fingerprint.

  • Cite this