Proteolytic degradation of the amyloid β-protein: The forgotten side of Alzheimer's disease

Malcolm A. Leissring

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Proteases have long played a central role in the molecular pathogenesis of Alzheimer's disease (AD), yet proteases that degrade the amyloid β-protein (Aβ) itself were largely ignored until only quite recently. Today, we know that Aβ-degrading proteases are critical regulators of brain Aβ levels in vivo, with evidence accumulating that their dysfunction may play a role in the etiology of AD. This review explores the historical factors that obscured this important aspect of amyloidogenesis, and discusses the many fresh insights it offers into the causes of and potential treatments for AD.

Original languageEnglish (US)
Pages (from-to)431-435
Number of pages5
JournalCurrent Alzheimer research
Volume3
Issue number5
DOIs
StatePublished - Dec 1 2006

Keywords

  • Alzheimer's disease
  • Amyloid
  • Amyloidogenesis
  • Catabolism
  • Proteases

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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