Proteolytic cleavage during chemotherapy-induced apoptosis

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Treatment with anticancer drugs sets into motion a morphologically and biochemically distinct type of cell death called apoptosis. Recent genetic and biochemical studies have suggested that proteases play a prominent role in the active phase of apoptotic cell death. Ongoing studies are aimed at identifying the proteases involved, the substrates that are cleaved, and the means by which the proteolytic process is regulated in nonapoptotic and apoptotic cells. The possibility that these findings will suggest new approaches to treating cancer and other diseases is discussed.

Original languageEnglish (US)
Pages (from-to)298-303
Number of pages6
JournalMolecular Medicine Today
Volume2
Issue number7
DOIs
StatePublished - 1996

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics

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