Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells

Wei Su, Nicole M. Chapman, Jun Wei, Hu Zeng, Yogesh Dhungana, Hao Shi, Jordy Saravia, Peipei Zhou, Lingyun Long, Sherri Rankin, Anil KC, Peter Vogel, Hongbo Chi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Su et al. show that mevalonate metabolism-driven protein geranylgeranylation and farnesylation orchestrate the respective differentiation and maintenance of effector Treg cells, by serving as rheostats for immunological receptor, mTORC1, and Rac signaling. These data establish a crucial role for metabolism-dependent posttranslational lipid modifications in Treg cell-mediated immune suppression.

Original languageEnglish (US)
Pages (from-to)996-1011.e7
JournalCell Metabolism
Volume32
Issue number6
DOIs
StatePublished - Dec 1 2020

Keywords

  • Fntb
  • immunometabolism
  • mTOR
  • Pggt1b
  • protein prenylation
  • Treg cells

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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