Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells

Wei Su; Nicole M. Chapman; Jun Wei; Hu Zeng; Yogesh Dhungana; Hao Shi; Jordy Saravia; Peipei Zhou; Lingyun Long; Sherri Rankin; Anil KC; Peter Vogel; Hongbo Chi

doi:10.1016/j.cmet.2020.10.022

Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector T_reg Cells

Wei Su, Nicole M. Chapman, Jun Wei, Hu Zeng, Yogesh Dhungana, Hao Shi, Jordy Saravia, Peipei Zhou, Lingyun Long, Sherri Rankin, Anil KC, Peter Vogel, Hongbo Chi

Rheumatology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Su et al. show that mevalonate metabolism-driven protein geranylgeranylation and farnesylation orchestrate the respective differentiation and maintenance of effector T_reg cells, by serving as rheostats for immunological receptor, mTORC1, and Rac signaling. These data establish a crucial role for metabolism-dependent posttranslational lipid modifications in T_reg cell-mediated immune suppression.

Original language	English (US)
Pages (from-to)	996-1011.e7
Journal	Cell Metabolism
Volume	32
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2020.10.022
State	Published - Dec 1 2020

Keywords

Fntb
Pggt1b
Treg cells
immunometabolism
mTOR
protein prenylation

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

Access to Document

10.1016/j.cmet.2020.10.022

Cite this

@article{f3e39c05209d442fa2ebffe55e4af3d9,

title = "Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells",

abstract = "Su et al. show that mevalonate metabolism-driven protein geranylgeranylation and farnesylation orchestrate the respective differentiation and maintenance of effector Treg cells, by serving as rheostats for immunological receptor, mTORC1, and Rac signaling. These data establish a crucial role for metabolism-dependent posttranslational lipid modifications in Treg cell-mediated immune suppression.",

keywords = "Fntb, Pggt1b, Treg cells, immunometabolism, mTOR, protein prenylation",

author = "Wei Su and Chapman, {Nicole M.} and Jun Wei and Hu Zeng and Yogesh Dhungana and Hao Shi and Jordy Saravia and Peipei Zhou and Lingyun Long and Sherri Rankin and Anil KC and Peter Vogel and Hongbo Chi",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = dec,

day = "1",

doi = "10.1016/j.cmet.2020.10.022",

language = "English (US)",

volume = "32",

pages = "996--1011.e7",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells

AU - Su, Wei

AU - Chapman, Nicole M.

AU - Wei, Jun

AU - Zeng, Hu

AU - Dhungana, Yogesh

AU - Shi, Hao

AU - Saravia, Jordy

AU - Zhou, Peipei

AU - Long, Lingyun

AU - Rankin, Sherri

AU - KC, Anil

AU - Vogel, Peter

AU - Chi, Hongbo

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Su et al. show that mevalonate metabolism-driven protein geranylgeranylation and farnesylation orchestrate the respective differentiation and maintenance of effector Treg cells, by serving as rheostats for immunological receptor, mTORC1, and Rac signaling. These data establish a crucial role for metabolism-dependent posttranslational lipid modifications in Treg cell-mediated immune suppression.

AB - Su et al. show that mevalonate metabolism-driven protein geranylgeranylation and farnesylation orchestrate the respective differentiation and maintenance of effector Treg cells, by serving as rheostats for immunological receptor, mTORC1, and Rac signaling. These data establish a crucial role for metabolism-dependent posttranslational lipid modifications in Treg cell-mediated immune suppression.

KW - Fntb

KW - Pggt1b

KW - Treg cells

KW - immunometabolism

KW - mTOR

KW - protein prenylation

UR - http://www.scopus.com/inward/record.url?scp=85096472876&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85096472876&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2020.10.022

DO - 10.1016/j.cmet.2020.10.022

M3 - Article

C2 - 33207246

AN - SCOPUS:85096472876

SN - 1550-4131

VL - 32

SP - 996-1011.e7

JO - Cell Metabolism

JF - Cell Metabolism

IS - 6

ER -