Protein metabolism in obesity: Effects of body fat distribution and hyperinsulinemia on leucine turnover

Michael D. Jensen, Morey W. Haymond

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

To examine whether moderate obesity and differences in body fat distribution are associated with abnormalities of protein metabolism, leucine turnover was measured in three groups of age-matched premenopausal women. Ten upper-body-obese (UB Ob), 10 lower-body-obese (LB Ob), and 10 nonobese (Non Ob) women were studied in an overnight postabsorptive condition (basal) and again during an infusion of low physiologic amounts of insulin (insulin clamp). Results showed that basal leucine carbon flux was greater (P < 0.05) in UB Ob and LB Ob women than in Non Ob women (2.96 ± 0.08 vs 3.14 ± 0.16 vs 2.68 ± 0.08 μmol · kg lean body mass-1 · min-1, respectively; x̄ ± SEM). Leucine carbon flux was not suppressed during the insulin-clamp study in UB Ob women but was in the LB Ob and Non Ob women. We conclude that moderate obesity is associated with increased proteolysis and that insulin's antiproteolytic actions are impaired in upper-body obesity. These findings could have implications for future studies of and treatment of obesity.

Original languageEnglish (US)
Pages (from-to)172-176
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume53
Issue number1
DOIs
StatePublished - Jan 1991

Keywords

  • Body fat distribution
  • Insulin
  • Leucine
  • Obesity
  • Proteolysis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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