Protein kinase D signaling in cancer

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Protein Kinase D is a serine/threonine kinase that shows responsiveness to phorbol esters and diacylglycerol and is a direct target for Src family kinases, RhoGTPases and protein kinase C. Thus PKD on first view represents a bona fide oncogene and is currently investigated for its potential as a drug target for multiple cancers. This is supported by the discovery that PKD promotes tumor cell survival in response to damaging stresses such as increases in reactive oxygen species, but also enhances cell proliferation and DNA synthesis in response to activation by growth factor and G-protein-coupled receptors. Based on these findings, the development of PKD inhibitors is progressed within the field. However, accumulating reports also suggest that PKD activation suppresses directed cell migration and invasion, suggesting that PKD expression may be needed for early tumorigenic events, but is downregulated during metastatic progression. This chapter describes the known roles of PKD isoenzymes in all aspects of tumor biology as well as the signaling mechanisms they use, and discusses their potential value as drug targets in cancer.

Original languageEnglish (US)
Title of host publicationCell Signaling & Molecular Targets in Cancer
PublisherSpringer New York
Pages245-271
Number of pages27
Volume9781461407300
ISBN (Print)9781461407300, 146140729X, 9781461407294
DOIs
StatePublished - May 1 2012

ASJC Scopus subject areas

  • Medicine(all)

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