Protein Kinase D enzymes as regulators of EMT and cancer cell invasion

Nisha Durand; Sahra Borges; Peter Storz

doi:10.3390/jcm5020020

Protein Kinase D enzymes as regulators of EMT and cancer cell invasion

Nisha Durand, Sahra Borges, Peter Storz

Cancer Biology

Research output: Contribution to journal › Review article › peer-review

Abstract

The Protein Kinase D (PKD) isoforms PKD1, PKD2, and PKD3 are effectors of the novel Protein Kinase Cs (nPKCs) and diacylglycerol (DAG). PKDs impact diverse biological processes like protein transport, cell migration, proliferation, epithelial to mesenchymal transition (EMT) and apoptosis. PKDs however, have distinct effects on these functions. While PKD1 blocks EMT and cell migration, PKD2 and PKD3 tend to drive both processes. Given the importance of EMT and cell migration to the initiation and progression of various malignancies, abnormal expression of PKDs has been reported in multiple types of cancers, including breast, pancreatic and prostate cancer. In this review, we discuss how EMT and cell migration are regulated by PKD isoforms and the significance of this regulation in the context of cancer development.

Original language	English (US)
Article number	20
Journal	Journal of Clinical Medicine
Volume	5
Issue number	2
DOIs	https://doi.org/10.3390/jcm5020020
State	Published - Feb 3 2016

Keywords

Cancer
EMT
Migration
PKD
Protein Kinase D

ASJC Scopus subject areas

General Medicine

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10.3390/jcm5020020

Cite this

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title = "Protein Kinase D enzymes as regulators of EMT and cancer cell invasion",

abstract = "The Protein Kinase D (PKD) isoforms PKD1, PKD2, and PKD3 are effectors of the novel Protein Kinase Cs (nPKCs) and diacylglycerol (DAG). PKDs impact diverse biological processes like protein transport, cell migration, proliferation, epithelial to mesenchymal transition (EMT) and apoptosis. PKDs however, have distinct effects on these functions. While PKD1 blocks EMT and cell migration, PKD2 and PKD3 tend to drive both processes. Given the importance of EMT and cell migration to the initiation and progression of various malignancies, abnormal expression of PKDs has been reported in multiple types of cancers, including breast, pancreatic and prostate cancer. In this review, we discuss how EMT and cell migration are regulated by PKD isoforms and the significance of this regulation in the context of cancer development.",

keywords = "Cancer, EMT, Migration, PKD, Protein Kinase D",

author = "Nisha Durand and Sahra Borges and Peter Storz",

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month = feb,

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doi = "10.3390/jcm5020020",

language = "English (US)",

volume = "5",

journal = "Journal of Clinical Medicine",

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T1 - Protein Kinase D enzymes as regulators of EMT and cancer cell invasion

AU - Durand, Nisha

AU - Borges, Sahra

AU - Storz, Peter

PY - 2016/2/3

Y1 - 2016/2/3

N2 - The Protein Kinase D (PKD) isoforms PKD1, PKD2, and PKD3 are effectors of the novel Protein Kinase Cs (nPKCs) and diacylglycerol (DAG). PKDs impact diverse biological processes like protein transport, cell migration, proliferation, epithelial to mesenchymal transition (EMT) and apoptosis. PKDs however, have distinct effects on these functions. While PKD1 blocks EMT and cell migration, PKD2 and PKD3 tend to drive both processes. Given the importance of EMT and cell migration to the initiation and progression of various malignancies, abnormal expression of PKDs has been reported in multiple types of cancers, including breast, pancreatic and prostate cancer. In this review, we discuss how EMT and cell migration are regulated by PKD isoforms and the significance of this regulation in the context of cancer development.

AB - The Protein Kinase D (PKD) isoforms PKD1, PKD2, and PKD3 are effectors of the novel Protein Kinase Cs (nPKCs) and diacylglycerol (DAG). PKDs impact diverse biological processes like protein transport, cell migration, proliferation, epithelial to mesenchymal transition (EMT) and apoptosis. PKDs however, have distinct effects on these functions. While PKD1 blocks EMT and cell migration, PKD2 and PKD3 tend to drive both processes. Given the importance of EMT and cell migration to the initiation and progression of various malignancies, abnormal expression of PKDs has been reported in multiple types of cancers, including breast, pancreatic and prostate cancer. In this review, we discuss how EMT and cell migration are regulated by PKD isoforms and the significance of this regulation in the context of cancer development.

KW - Cancer

KW - EMT

KW - Migration

KW - PKD

KW - Protein Kinase D

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DO - 10.3390/jcm5020020

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JO - Journal of Clinical Medicine

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Protein Kinase D enzymes as regulators of EMT and cancer cell invasion

Abstract

Keywords

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