Protein kinase C isoforms in the normal pancreas and in pancreatic disease

Alicia K. Fleming, Peter Storz

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Protein Kinase C isoforms have been implicated in regulating multiple processes within the healthy pancreas. Moreover, their dysregulation contributes to all aspects of pancreatic disease. In this review, with a focus on acinar, ductal, and islet cells, we highlight the roles and contributions of the different PKC isoforms to normal pancreas function. We also discuss the contribution of PKC enzymes to pancreatic diseases, including insulin resistance and diabetes mellitus, as well as pancreatitis and the development and progression of pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalCellular Signalling
Volume40
DOIs
StatePublished - Dec 2017

Keywords

  • PKC
  • Pancreas
  • Pancreatic cancer
  • Pancreatitis
  • Protein kinase C

ASJC Scopus subject areas

  • Cell Biology

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