Protein kinase Cι

A versatile oncogene in the lung

Research output: Contribution to journalArticle

Abstract

We have recently demonstrated that protein kinase Cι (PKCι) promotes a stem-like, tumor-initiating cell phenotype in KRAS-driven lung adenocarcinoma by activating a novel ELF3-NOTCH3 signaling axis.1 Combined PKCι and NOTCH inhibition was identified as a novel strategy for the treatment of KRAS-driven lung adenocarcinoma.

Original languageEnglish (US)
Article numbere1190886
JournalMolecular and Cellular Oncology
DOIs
StateAccepted/In press - Jan 1 2018

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Oncogenes
Protein Kinase C
Lung
Neoplastic Stem Cells
Phenotype
Adenocarcinoma of lung

Keywords

  • Gene amplification
  • lung adenocarcinoma
  • lung squamous cell carcinoma
  • non-small cell lung cancer
  • Protein Kinase Ciota
  • therapeutic targeting

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

Cite this

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title = "Protein kinase Cι: A versatile oncogene in the lung",
abstract = "We have recently demonstrated that protein kinase Cι (PKCι) promotes a stem-like, tumor-initiating cell phenotype in KRAS-driven lung adenocarcinoma by activating a novel ELF3-NOTCH3 signaling axis.1 Combined PKCι and NOTCH inhibition was identified as a novel strategy for the treatment of KRAS-driven lung adenocarcinoma.",
keywords = "Gene amplification, lung adenocarcinoma, lung squamous cell carcinoma, non-small cell lung cancer, Protein Kinase Ciota, therapeutic targeting",
author = "Fields, {Alan P} and Ali, {Syed A.} and Verline Justilien and Murray, {Nicole R}",
year = "2018",
month = "1",
day = "1",
doi = "10.1080/23723556.2016.1190886",
language = "English (US)",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",

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AU - Fields, Alan P

AU - Ali, Syed A.

AU - Justilien, Verline

AU - Murray, Nicole R

PY - 2018/1/1

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AB - We have recently demonstrated that protein kinase Cι (PKCι) promotes a stem-like, tumor-initiating cell phenotype in KRAS-driven lung adenocarcinoma by activating a novel ELF3-NOTCH3 signaling axis.1 Combined PKCι and NOTCH inhibition was identified as a novel strategy for the treatment of KRAS-driven lung adenocarcinoma.

KW - Gene amplification

KW - lung adenocarcinoma

KW - lung squamous cell carcinoma

KW - non-small cell lung cancer

KW - Protein Kinase Ciota

KW - therapeutic targeting

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