Abstract
We have recently demonstrated that protein kinase Cι (PKCι) promotes a stem-like, tumor-initiating cell phenotype in KRAS-driven lung adenocarcinoma by activating a novel ELF3-NOTCH3 signaling axis.1 Combined PKCι and NOTCH inhibition was identified as a novel strategy for the treatment of KRAS-driven lung adenocarcinoma.
Original language | English (US) |
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Article number | e1190886 |
Journal | Molecular and Cellular Oncology |
Volume | 5 |
Issue number | 5 |
DOIs |
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State | Published - Sep 3 2018 |
Keywords
- Gene amplification
- Protein Kinase Ciota
- lung adenocarcinoma
- lung squamous cell carcinoma
- non-small cell lung cancer
- therapeutic targeting
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research