Protein kinase Cι: A versatile oncogene in the lung

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations

Abstract

We have recently demonstrated that protein kinase Cι (PKCι) promotes a stem-like, tumor-initiating cell phenotype in KRAS-driven lung adenocarcinoma by activating a novel ELF3-NOTCH3 signaling axis.1 Combined PKCι and NOTCH inhibition was identified as a novel strategy for the treatment of KRAS-driven lung adenocarcinoma.

Original languageEnglish (US)
Article numbere1190886
JournalMolecular and Cellular Oncology
Volume5
Issue number5
DOIs
StatePublished - Sep 3 2018

Keywords

  • Gene amplification
  • Protein Kinase Ciota
  • lung adenocarcinoma
  • lung squamous cell carcinoma
  • non-small cell lung cancer
  • therapeutic targeting

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

Fingerprint Dive into the research topics of 'Protein kinase Cι: A versatile oncogene in the lung'. Together they form a unique fingerprint.

Cite this