Protein kinase Cι: A versatile oncogene in the lung

Research output: Contribution to journalArticle

Abstract

We have recently demonstrated that protein kinase Cι (PKCι) promotes a stem-like, tumor-initiating cell phenotype in KRAS-driven lung adenocarcinoma by activating a novel ELF3-NOTCH3 signaling axis.1 Combined PKCι and NOTCH inhibition was identified as a novel strategy for the treatment of KRAS-driven lung adenocarcinoma.

Original languageEnglish (US)
Article numbere1190886
JournalMolecular and Cellular Oncology
DOIs
StateAccepted/In press - Jan 1 2018

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Keywords

  • Gene amplification
  • lung adenocarcinoma
  • lung squamous cell carcinoma
  • non-small cell lung cancer
  • Protein Kinase Ciota
  • therapeutic targeting

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

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